Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition
Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition
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DOI：
10.1684/ecn.2013.0328
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发表时间：
2013-03-01
影响因子：
2.8
通讯作者：
Solgi, Ghasem
中科院分区：
文献类型：
--
作者：
Keikhaei, Bijan;Mohseni, Ali Reza;Solgi, Ghasem
Objective: This study aimed to evaluate serum levels of pro-inflammatory cytokines and TGF-beta in sickle cell disease (SCD) patients, and to compare the results during vaso-occlusive crisis (VOC) or steady state (StSt) conditions. Methods: 54 SCD patients (37HbSS and 17S beta(+)Thal) were enrolled in the study and evaluated in two groups as follows; group A consisted of 39 VOC patients and group B comprised 15 StSt patients. Nineteen healthy volunteers were included as controls. Circulating levels of IL-1, IL-6, IL-8, IL-17, TNF-alpha and TGF-beta were measured using ELISA. Results: Patients in VOC showed higher mean levels of all cytokines than those found in steady-state patients, but this was only marginally significant for IL-8 levels (P = 0.08). Increased levels of TGF-beta and IL-17 were found in StSt patients versus normal controls (P = 0.004 and P
