Superior colliculus bidirectionally modulates choice activity in frontal cortex.
Superior colliculus bidirectionally modulates choice activity in frontal cortex.
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DOI：
10.1038/s41467-023-43252-9
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发表时间：
2023-11-14
影响因子：
16.6
通讯作者：
Li, Nuo
中科院分区：
文献类型：
--
作者：
Thomas, Alyse;Yang, Weiguo;Wang, Catherine;Tipparaju, Sri Laasya;Chen, Guang;Sullivan, Brennan;Swiekatowski, Kylie;Tatam, Mahima;Gerfen, Charles;Li, Nuo
行动选择是通过潜在选择选项之间的竞争而产生的。在决策过程中，选择竞争的神经相关性在额叶皮层和下游上丘（SC）中被观察到，但这些区域如何相互作用以调解选择竞争仍未解决。本研究报道SC可以双向调节选择竞争和驱动额叶皮层的选择活动。在小鼠中，额叶皮层和SC的地形匹配区域形成了定向舔舐的下行运动通路和通过丘脑的再入回路。在决策过程中，额叶皮层和SC中不同的神经元群编码相反的舔舐方向，并表现出竞争性相互作用。SC gaba能神经元编码同侧选择，局部抑制编码对侧选择的谷氨酸能神经元。激活或抑制这些细胞类型可以双向驱动额叶皮层的选择活动。因此，这些结果确定SC是在更广泛的行动选择网络中调节选择竞争的主要位点。大脑皮层和皮层下多个区域与决策有关，但它们之间的因果关系尚不清楚。在这里，作者确定了细胞和电路的相互作用，使皮质决策动力学和行为偏向。
Action selection occurs through competition between potential choice options. Neural correlates of choice competition are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate choice competition remains unresolved. Here we report that SC can bidirectionally modulate choice competition and drive choice activity in frontal cortex. In the mouse, topographically matched regions of frontal cortex and SC formed a descending motor pathway for directional licking and a re-entrant loop via the thalamus. During decision-making, distinct neuronal populations in both frontal cortex and SC encoded opposing lick directions and exhibited competitive interactions. SC GABAergic neurons encoded ipsilateral choice and locally inhibited glutamatergic neurons that encoded contralateral choice. Activating or suppressing these cell types could bidirectionally drive choice activity in frontal cortex. These results thus identify SC as a major locus to modulate choice competition within the broader action selection network. Multiple cortical and subcortical brain regions are implicated in decision-making, yet their causal interactions remain unclear. Here, the authors identified cellular and circuit interactions that bias cortical decision-making dynamics and behavior.