Inflammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
Inflammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
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DOI：
10.1128/iai.65.8.3126-3131.1997
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发表时间：
1997-08-01
影响因子：
3.1
通讯作者：
Schauer, DB
中科院分区：
文献类型：
--
作者：
Cahill, RJ;Foltz, CJ;Schauer, DB
炎症性肠病（IBD）被认为是由对肠道植物群的异常免疫应答或对特定病原体的正常免疫应答引起的，迄今为止还没有研究将这两种因素结合起来。严重联合免疫缺陷（scid）突变纯合子小鼠发生IBD，并通过过继转移表达高水平CD45RB的CD4（+）T细胞这些小鼠在无菌条件下不发生IBD，这表明在病变的发病机制中存在不确定的肠道植物群。在对照的重复研究中，评估了单一鼠病原体肝螺杆菌（Helicobacter hepaticus）与异常免疫应答组合对IBD发生的影响。Hepaticus感染和CD45RB（高）CD4（+）T细胞重建导致与在人IBD中观察到的类似的严重疾病表达。该研究表明，IBD在小鼠中的发展是在单一鼠病原体Hepaticus存在下异常免疫应答的结果。宿主免疫和单一病原体在该鼠系统中的相互作用提供了一种新的人类IBD模型，IBD是由细菌感染引发的免疫介导的病症。
Inflammatory bowel disease (IBD) is thought to result from either an abnormal immunological response to enteric flora or a normal immunological response to a specific pathogen, No study to date has combined both factors, The present studies were carried out with an immunologically manipulated mouse model of IBD, Mice homozygous for the severe combined immunodeficiency (scid) mutation develop IBD with adoptive transfer of CD4(+) T cells expressing high levels of CD45RB (CD45RB(high) CD4(+) T cells), These mice do not develop IBD in germfree conditions, implicating undefined intestinal flora in the pathogenesis of lesions, In controlled duplicate studies, the influence of a single murine pathogen, Helicobacter hepaticus, in combination with the abnormal immunological response on the development of IBD was assessed, The combination of H. hepaticus infection and CD45RB(high) CD4(+) T-cell reconstitution resulted in severe disease expression similar to that observed in human IBD, This study demonstrates that IBD develops in mice as a consequence of an abnormal immune response in the presence of a single murine pathogen, H, hepaticus. The interaction of host immunity and a single pathogen in this murine system provides a novel model of human IBD, an immunity-mediated condition triggered by bacterial infection.