TRANSFORMING GROWTH FACTOR-BETA-1 EXPRESSION IN IRRADIATED LIVER
TRANSFORMING GROWTH FACTOR-BETA-1 EXPRESSION IN IRRADIATED LIVER
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DOI：
10.2307/3577586
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发表时间：
1990-04-01
影响因子：
3.4
通讯作者：
JIRTLE, RL
中科院分区：
文献类型：
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作者：
ANSCHER, MS;CROCKER, IR;JIRTLE, RL
照射后9个月，照射大鼠肝脏中转化生长因子-β 1（TGF-β 1）的表达以剂量依赖性方式增加。TGF-β 1的表达主要局限于肝的中央周围区域的肝细胞，并且TGF-β 1强阳性的肝细胞的百分比与纤维化的程度显著相关。我们进一步表明，将TGF-β 1局部注射到正常大鼠肝脏中在注射部位引起强烈的纤维化反应。这些结果表明，响应于辐射损伤的肝TGF-β 1浓度的增加可能在辐射性肝炎的发病机制中是重要的。还发现TGF-β 1在未照射的人肝细胞中的浓度显著高于在正常大鼠肝细胞中的浓度，这意味着人发生放射性肝炎的倾向可能部分地由正常人肝中发现的TGF-β 1水平升高引起。
The expression of transforming growth factor-.beta.1 (TGF-.beta.1) in the liver of irradiated rats was increased in a dose-dependent fashion 9 months after irradiation. Expression of TGF-.beta.1 was confined primarily to hepatocytes in the pericentral region of the liver, and the percentage of hepatocytes strongly positive for TGF-B1 was significantly correlated with the extent of fibrosis. We further showed that a localized injection of TGF-.beta.1 into normal rat liver elicited a strong fibrotic reaction at the injection site. These results suggest that the increased hepatic concentration of TGF-.beta.1 in response to radiation injury may be important in the pathogenesis of radiation hepatitis. TGF-.beta.1 was also found to be present at a significantly higher concentration in unirradiated human hepatocytes than in normal rat hepatocytes, implying that the propensity for humans to develop radiation hepatitis may result in part from the elevated levels of TGF-.beta.1 normally found in human liver.