The locus coeruleus mediates behavioral flexibility.
The locus coeruleus mediates behavioral flexibility.
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DOI：
10.1016/j.celrep.2022.111534
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发表时间：
2022-10-25
期刊：
影响因子：
8.8
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中科院分区：
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行为灵活性是指根据环境变化调整行为策略的能力。该领域的一个主要假设认为，蓝斑（LC）神经元的活动在调节行为灵活性中起重要作用。为了验证这一假设，我们开发了一种基于触觉的规则转移检测任务，在该任务中，小鼠以依赖于上下文的方式对左右须偏转做出反应，并表现出不同程度的转换行为。在任务执行过程中，以毫秒精度记录光遗传学标记的LC神经元的尖峰活动，揭示了LC基线活动与行为灵活性之间显著的分级相关性，其中规则改变后更高的基线活动与更快的行为转换到新规则相关。光遗传激活增加基线LC活性加速任务切换和改善任务性能。总的来说，我们的研究为揭示LC活动与行为灵活性之间的联系提供了重要的证据。McBurney-Lin和Vargova等人在基于触觉的规则转移任务中测量蓝斑（LC）神经元的尖峰活动，以测试LC在行为灵活性中的作用。LC基线活动与规则转换速度有显著的相关性。增加LC基线活动有助于行为转换。
Behavioral flexibility is the ability to adjust behavioral strategies in response to changing environmental contingencies. A major hypothesis in the field posits that the activity of neurons in the locus coeruleus (LC) plays an important role in mediating behavioral flexibility. To test this hypothesis, we developed a tactile-based rule-shift detection task in which mice responded to left and right whisker deflections in a context-dependent manner and exhibited varying degrees of switching behavior. Recording spiking activity from optogenetically tagged neurons in the LC at millisecond precision during task performance revealed a prominent graded correlation between baseline LC activity and behavioral flexibility, where higher baseline activity following a rule change was associated with faster behavioral switching to the new rule. Increasing baseline LC activity with optogenetic activation accelerated task switching and improved task performance. Overall, our study provides important evidence to reveal the link between LC activity and behavioral flexibility. McBurney-Lin and Vargova et al. measure spiking activity from neurons in the locus coeruleus (LC) during a tactile-based rule-shift task to test the role of LC in behavioral flexibility. LC baseline activity exhibits a prominent correlation with the speed of rule switching. Increasing LC baseline activity facilitates behavioral switching.