Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus
Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus
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DOI：
10.1007/s003350010129
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发表时间：
2000-08-01
期刊：
影响因子：
2.5
通讯作者：
Shiroishi, T
中科院分区：
文献类型：
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作者：
Koide, T;Moriwaki, K;Shiroishi, T
老鼠行为的许多方面已经通过只使用相对较少的可用的实验室菌株样本进行了研究。这些实验室小鼠是从所谓的“花式小鼠”衍生而来的，在大多数情况下，它们在近亲交配之前都经过了广泛的驯化。因此，实验小鼠的行为表现可能与没有被刻意驯化的种群表现出的非常不同。分析老鼠行为的另一个固有问题是，目前可用的品系之间的遗传多样性有限。在这方面，使用来自各种野生小鼠的菌株应该提供一种识别新的行为表型的方法。我们用来自不同亚种的野生小鼠BFM/2、NJL、BLG2、HMI、CAST/EI、KJR、SWN和MSM的若干小鼠品系的雌性品系、花式小鼠品系JF1和两个实验室品系研究了几种行为表型。C57BL/6和DBA/1。在本报告中，进行了运动活动、明暗转换、被动和主动回避以及伤害感受的测试，结果表明，菌株之间的行为模式差异很大，而菌株内的变异性较小。我们还发现两个品系KJR和SWN都具有良好的学习能力，而BLG2小鼠在被动和主动回避学习中都表现出障碍。
Many aspects of mouse behavior have been studied by using only a relatively small sample of available laboratory strains. These laboratory mice were derived from the so-called "fancy mouse" and in most cases underwent extensive domestication before inbreeding. Thus, the behavioral repertoire of the laboratory mouse may be very different from that exhibited by stocks that have not been deliberately domesticated. Another inherent problem in analyzing mouse behavior is that genetic diversity is limited among currently available strains. In this respect, the use of strains that are derived from a variety of wild mice should provide a means to identifying novel behavioral phenotypes. We have investigated several behavioral phenotypes, using females of a number of mouse strains derived from wild mice of different subspecies, BFM/2, NJL, BLG2, HMI, CAST/Ei, KJR, SWN and MSM; a strain derived from fancy mice, JF1; and two laboratory strains. C57BL/6 and DBA/1. In this report, tests for locomotor activity, light-dark transitions, passive and active avoidance, and nociception were conducted, The results show great diversity of behavioral patterns between strains in contrast to less within-strain variability. We also found that two strains, KJR and SWN, both have good learning ability, whereas BLG2 mice exhibit impairment in both passive and active avoidance learning.