Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets
Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets
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DOI：
10.1016/j.domaniend.2005.02.003
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发表时间：
2005-05-01
影响因子：
2.1
通讯作者：
Fan, MZ
中科院分区：
文献类型：
--
作者：
Tang, ZR;Yin, YL;Fan, MZ
本试验旨在研究饲粮中添加壳聚糖（COS）和半乳甘露寡糖（GMOS）对早期断奶仔猪部分血清生化指标、血清生长激素（GH）和胰岛素样生长因子-I（IGF-I）水平以及肝脏和长臀肌IGF-I mRNA表达的影响。选用26头15日龄的杜×长×约克郡仔猪。仔猪在哺乳期间可获得蠕动饲料。在研究开始时，处死6头仔猪进行采样。将其余20头仔猪单独饲养于代谢笼中，随机分为对照组、抗生素组（林可霉素110 mg/kg）、COS组（COS 0.025%）和GMOS组（GMOS 0.20%），进行为期2周的饲养试验。添加COS和GMOS后，血尿素氮（BUN）水平降低，血清总蛋白浓度升高（P < 0.05）。日粮中添加COS和GMOS还能显著提高血清GH和IGF-I水平（P < 0.05），同时沿着肝脏和肌肉IGF-I mRNA丰度的增加。日粮中添加COS和GMOS等低聚糖可提高早期断奶仔猪血浆GH和IGF-I水平，从而改善仔猪生长和饲料转化效率。(c)2005年爱思唯尔公司All rights reserved.
The study was to determine effects of dietary supplementation of chitosan (COS) and galacto-mannan-oligosaccharids (GMOS) on some serum biochemical indices, serum growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels, and hepatic and long gissimus muscle IGF-I mRNA expression in early-weaned piglets. Twenty six Duroc x Landrace x Yorkshire piglets at the age of 15 days were used. The piglets had access to creep feed during the suckling. Six piglets were sacrificed for sampling at the beginning of the study. The other 20 piglets were individually housed in metabolic cages and randomly allotted to four corn and soybean meal-based diets including the control group, the antibiotic group with 110 mg lincomycin/kg diet, the COS group containing 0.025% COS, and the GMOS group with 0.20% GMOS, respectively, in a 2-week feeding experiment. Blood urea nitrogen (BUN) level was reduced whereas serum total protein concentration was increased (P < 0.05) in responses to the COS and GMOS supplementation. Dietary supplementation of COS and GMOS also increased (P < 0.05) the serum GH and IGF-I levels along with enhanced hepatic and the muscle IGF-I mRNA abundance. Dietary supplementation of oligosaccharides such as COS and GMOS may improve growth and feed conversion efficiency by increasing plasma GH and IGF-I levels, in the early-weaned piglets. (c) 2005 Elsevier Inc. All rights reserved.