Calibrations and validations of biological models with an application on the renal fibrosis
Calibrations and validations of biological models with an application on the renal fibrosis
复制标题
肾纤维化生物学模型的校准和验证
DOI：
10.1002/cnm.3329
复制
发表时间：
2020
影响因子：
2.1
通讯作者：
Lin, Guang
中科院分区：
文献类型：
--
作者：
Karagiannis, Georgios;Hao, Wenrui;Lin, Guang
我们校准了Hao等人的肾小管间质纤维化的数学模型，该模型用于探索狼疮肾炎的潜在药物，针对84例患者的真实数据集。为此，我们提出了一个通用的校准程序，也可用于其他生物系统的校准分析。该过程的核心思想是设计一个贝叶斯高斯过程（GP）仿真器，该仿真器可以用作纤维化数学模型的替代品，该模型在每个输入值下大规模运行计算成本很高。该程序依赖于通过基于GP的敏感性分析来检测有影响的模型参数，并通过指定针对应用程序定制的最大似然标准来校准它们，该标准通过贝叶斯全局优化进行优化。
We calibrate a mathematical model of renal tubulointerstitial fibrosis by Hao et al which is used to explore potential drugs for Lupus Nephritis, against a real data set of 84 patients. For this purpose, we present a general calibration procedure which can be used for the calibration analysis of other biological systems as well. Central to the procedure is the idea of designing a Bayesian Gaussian process (GP) emulator that can be used as a surrogate of the fibrosis mathematical model which is computationally expensive to run massively at every input value. The procedure relies on detecting influential model parameters by a GP‐based sensitivity analysis, and calibrating them by specifying a maximum likelihood criterion, tailored to the application, which is optimized via Bayesian global optimization.
元模型全球敏感性指数估计的不确定性评估
DOI：
--
发表时间：
2014
期刊：
影响因子：
--
作者：
Alexandre Janon;M. Nodet;C. Prieur
通讯作者：
C. Prieur
影响因子：
2.2
作者：
Gramacy, Robert B.;Lee, Herbert K. H.
通讯作者：
Lee, Herbert K. H.