Acute respiratory distress syndrome.
Acute respiratory distress syndrome.
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DOI：
10.1016/s0140-6736(21)00439-6
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发表时间：
2021-08-14
期刊：
影响因子：
--
通讯作者：
Calfee CS
中科院分区：
文献类型：
--
作者：
Meyer NJ;Gattinoni L;Calfee CS
急性呼吸窘迫综合征（ARDS）是一种急性呼吸系统疾病，其特征是双侧胸部X线摄影显示混浊，伴有非心源性肺水肿引起的严重低氧血症。COVID-19大流行导致ARDS增加，并凸显了与该综合征相关的挑战，包括其不可接受的高死亡率和缺乏有效的药物治疗。在这次研讨会上，我们总结了当前关于ARDS流行病学和危险因素，鉴别诊断，以及机械通气和支持性治疗的循证临床管理的知识，并讨论了争议和正在进行的研究领域。虽然研讨会的重点是任何原因引起的ARDS，但我们也考虑了COVID-19相关的ARDS与其他原因引起的ARDS的共性和区别。
Acute respiratory distress syndrome (ARDS) is an acute respiratory illness characterised by bilateral chest radiographical opacities with severe hypoxaemia due to non-cardiogenic pulmonary oedema. The COVID-19 pandemic has caused an increase in ARDS and highlighted challenges associated with this syndrome, including its unacceptably high mortality and the lack of effective pharmacotherapy. In this Seminar, we summarise current knowledge regarding ARDS epidemiology and risk factors, differential diagnosis, and evidence-based clinical management of both mechanical ventilation and supportive care, and discuss areas of controversy and ongoing research. Although the Seminar focuses on ARDS due to any cause, we also consider commonalities and distinctions of COVID-19-associated ARDS compared with ARDS from other causes.