DIHYDROTESTOSTERONE IN PROSTATIC HYPERTROPHY .1. FORMATION AND CONTENT OF DIHYDROTESTOSTERONE IN HYPERTROPHIC PROSTATE OF MAN
DIHYDROTESTOSTERONE IN PROSTATIC HYPERTROPHY .1. FORMATION AND CONTENT OF DIHYDROTESTOSTERONE IN HYPERTROPHIC PROSTATE OF MAN
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DOI：
10.1172/jci106391
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发表时间：
1970-01-01
影响因子：
15.9
通讯作者：
WILSON, JD
中科院分区：
文献类型：
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作者：
SIITERI, PK;WILSON, JD
为了探讨雄激素与男性前列腺肥大的关系，测定了正常和肥大前列腺组织中睾酮、双氢睾酮和雄烯二酮的浓度以及睾酮转化为双氢睾酮的速率。首先，采用双同位素衍生技术测定15例正常前列腺和10例肥大前列腺组织中雄激素含量。雄烯二酮和睾酮含量在两种组织中无显著差异，但肥大组织中双氢睾酮含量（0.60 ±0.10 μg/100 g）显著高于正常腺体（0.13 ±0.05 μg/100 g）。第二，在三个正常前列腺和四个腺体早期肥大的区域进行了研究，它表明，双氢睾酮含量是两个和三倍以上的尿道周围地区，前列腺肥大通常开始比在外部地区的腺体。最后，睾酮转化为双氢睾酮的速率已在标准化条件下，从4个正常和20个肥大前列腺的组织切片进行了测量。两种腺体的双氢睾酮生成速率无显著差异（6.0 ±0.8和7.8 ±0.5 μμ mol/15 mg组织/hr）。虽然双氢睾酮蓄积发生的机制仍然无法解释，但双氢睾酮的局部蓄积可能参与了男性前列腺肥大的发病机制。图片
To explore the relation between androgens and prostatic hypertrophy in man, the concentrations of testosterone, dihydrotestosterone, and androstenedione and the rate of conversion of testosterone to dihydrotestosterone have been measured in normal and hypertrophic prostate tissue. First, a double isotope derivative technique was adapted for the measurement of tissue androgen content in 15 normal and 10 hypertrophic prostates. Although there was no significant difference in the content of androstenedione and testosterone between the two types of tissue, the content of dihydrotestosterone was significantly greater in the hypertrophic tissue (0.60 ±0.10 μg/100 g) than in the normal glands (0.13 ±0.05 μg/100 g). Second, a regional study was performed in three normal prostates and four glands with early hypertrophy, and it was demonstrated that the dihydrotestosterone content was two and three fold greater in the periurethral area where prostatic hypertrophy usually commences than in the outer regions of the gland. Finally, the rate of conversion of testosterone to dihydrotestosterone has been measured under standardized conditions in tissue slices from 4 normal and 20 hypertrophic prostates. There was no significant difference in the rate of dihydrotestosterone formation between the two types of gland (6.0 ±0.8 and 7.8 ±0.5 μμmoles/15 mg of tissue per hr). While the mechanism by which dihydrotestosterone accumulation occurs remains unexplained, it is possible that the local accumulation of dihydrotestosterone may be involved in the pathogenesis of prostatic hypertrophy in man.Images