Current concepts on endothelial stem cells definition, location, and markers.
Current concepts on endothelial stem cells definition, location, and markers.
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DOI：
10.1002/sctm.21-0022
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发表时间：
2021-11
影响因子：
6
通讯作者：
Medina RJ
中科院分区：
文献类型：
--
作者：
Chambers SEJ;Pathak V;Pedrini E;Soret L;Gendron N;Guerin CL;Stitt AW;Smadja DM;Medina RJ
缺血性血管疾病是世界范围内死亡率和发病率的主要原因，在灌注不足的组织中进行血管再生是一个有价值的治疗目标。输送内皮干细胞/祖细胞修复受损血管，再灌注缺氧组织，防止细胞死亡，从而减少组织炎症和纤维化的想法具有很强的科学依据和临床价值。不同的实验室提出了内皮干细胞/祖细胞候选者。这造成了混乱，因为这些基于分离方法、表征和修复生物学的细胞定义之间存在着深刻的差异。在此，基于干细胞生物学原理提出了一个更严格的定义。尽管临床前研究通常是有希望的，但临床试验的结果却高度矛盾，并突出了与令人失望的治疗效果相关的多重挑战。本文回顾了该领域的最新成就，并讨论了目前发展内皮干细胞治疗的困难。新出现的证据反驳了传统观点，即骨髓是这些细胞的来源，并支持血管壁作为这些组织驻留内皮干细胞的生态位。此外，还描述了用于识别内皮干细胞的新标记，包括CD157、EPCR和CD31low VEGFR2low IL33+ Sox9+。了解内皮干细胞/祖细胞。
Ischemic vascular disease is a major cause of mortality and morbidity worldwide, and regeneration of blood vessels in perfusion‐deficient tissues is a worthwhile therapeutic goal. The idea of delivering endothelial stem/progenitor cells to repair damaged vasculature, reperfuse hypoxic tissue, prevent cell death, and consequently diminish tissue inflammation and fibrosis has a strong scientific basis and clinical value. Various labs have proposed endothelial stem/progenitor cell candidates. This has created confusion, as there are profound differences between these cell definitions based on isolation methodology, characterization, and reparative biology. Here, a stricter definition based on stem cell biology principles is proposed. Although preclinical studies have often been promising, results from clinical trials have been highly contradictory and served to highlight multiple challenges associated with disappointing therapeutic benefit. This article reviews recent accomplishments in the field and discusses current difficulties when developing endothelial stem cell therapies. Emerging evidence that disputes the classic view of the bone marrow as the source for these cells and supports the vascular wall as the niche for these tissue‐resident endothelial stem cells is considered. In addition, novel markers to identify endothelial stem cells, including CD157, EPCR, and CD31low VEGFR2low IL33+ Sox9+, are described. Understanding endothelial stem/progenitor cells.
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影响因子：
23.9
作者：
Chen, Qi;Liu, Yang;Adams, Ralf H.
通讯作者：
Adams, Ralf H.
影响因子：
20.3
作者：
Fares, Iman;Chagraoui, Jalila;Sauvageau, Guy
通讯作者：
Sauvageau, Guy
DOI：
10.1165/rcmb.2014-0185oc
发表时间：
2015-10-01
影响因子：
6.4
作者：
Kawasaki, Takeshi;Nishiwaki, Tetsu;Tatsumi, Koichiro
通讯作者：
Tatsumi, Koichiro
影响因子：
3.7
作者：
Huizer K;Mustafa DAM;Spelt JC;Kros JM;Sacchetti A
通讯作者：
Sacchetti A
影响因子：
4.8
作者：
Guerin CL;Guyonnet L;Goudot G;Revets D;Konstantinou M;Chipont A;Chocron R;Blandinieres A;Khider L;Rancic J;Peronino C;Debuc B;Cras A;Knosp C;Latremouille C;Capel A;Ollert M;Diehl JL;Jansen P;Planquette B;Sanchez O;Gaussem P;Mirault T;Carpentier A;Gendron N;Smadja DM
通讯作者：
Smadja DM