Peripheral injection of arginine8-vasopressin increases Fos in specific brain areas.
Peripheral injection of arginine8-vasopressin increases Fos in specific brain areas.
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外周注射精氨酸 8-加压素可增加特定大脑区域的 Fos。
DOI：
10.1016/0014-2999(95)00258-m
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发表时间：
1995
影响因子：
5
通讯作者：
Kalant,H
中科院分区：
文献类型：
--
作者：
Wu,PH;Lança,AJ;Liu,JF;Man,CF;Kalant,H
习得的行为和对乙醇的耐受性可以通过外周注射精氨酸8-加压素（加压素）来维持，否则它们会消失。然而，大脑中这种作用的部位尚未明确。使用针对 Fos 和 Fos 样蛋白的多克隆抗体，我们证明了皮下注射后 2 小时，大鼠下丘脑的视交叉上核、视上核和室旁核中免疫反应性 Fos 和 Fos 样蛋白增加，而梨状皮层和杏仁核增加较少。注射加压素。我们的结果表明，外源性加压素可能通过激活特定大脑区域的细胞立即早期基因来发挥其中心作用。
Learned behaviors and tolerance to ethanol can be maintained by peripheral injection of arginine8-vasopressin (vasopressin) under conditions in which they would otherwise be lost. However, the sites of this action in the brain have not been clearly identified. Using a polyclonal antibody raised against Fos and Fos-like proteins, we have demonstrated increases in immunoreactive Fos and Fos-like proteins in the suprachiasmatic, supraoptic and paraventricular nuclei of the hypothalamus, and lesser increases in piriform cortex and amygdala, of the rat 2 h after a s.c. injection of vasopressin. Our results suggest that the exogenous vasopressin may exert its central action by activating a cellular immediate early gene in specific brain regions.