THE EFFECT OF INTRAVENOUS LIDOCAINE ON NOCICEPTIVE PROCESSING IN DIABETIC NEUROPATHY
THE EFFECT OF INTRAVENOUS LIDOCAINE ON NOCICEPTIVE PROCESSING IN DIABETIC NEUROPATHY
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DOI：
10.1016/0304-3959(90)91047-m
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发表时间：
1990-01-01
期刊：
影响因子：
7.4
通讯作者：
DEJGARD, A
中科院分区：
文献类型：
--
作者：
BACH, FW;JENSEN, TS;DEJGARD, A
在一项双盲对照设计中，7例疼痛性糖尿病神经病变患者在30 min内静脉注射利多卡因5 mg/kg或生理盐水。在3例患者的伤害性屈曲反射阈值可以确定。利多卡因使阈值增加，并在10天内恢复到输注前水平。利多卡因还使4名健康受试者的阈值增加，但不影响霍夫曼反射。这些结果表明，利多卡因在脊髓水平发挥其缓解糖尿病神经病变疼痛的作用。
In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffman reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.