Surface Sensing for Biofilm Formation in Pseudomonas aeruginosa.
Surface Sensing for Biofilm Formation in Pseudomonas aeruginosa.
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DOI：
10.3389/fmicb.2017.02671
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发表时间：
2017
影响因子：
5.2
通讯作者：
Chang CY
中科院分区：
文献类型：
--
作者：
Chang CY
在生物或非生物表面聚集和形成生物膜是细菌在各种条件下普遍存在的行为。在临床环境中，生物膜的持续存在增加了医疗保健相关感染的风险，并带来了巨大的医疗保健和经济负担。生物膜内的细菌受到保护，免受外部损伤和宿主免疫系统的攻击，并可以交换基因组信息，包括耐药性基因。从医疗器械或宿主组织上附着的生物膜分散的细菌细胞也可能成为进一步感染的来源。了解细菌如何形成生物膜对于解决生物膜相关的感染和传播至关重要。生物膜已经被认为是适应不同环境的连续生长模式，从细菌细胞感测其附着到表面开始，然后切换细胞生理状态以形成成熟的生物膜。了解细菌基因调控网络和初始表面附着后生物膜形成的决策过程至关重要。铜绿假单胞菌是研究细菌种群行为的模式微生物之一。一些假说和研究表明，胞外大分子和附属物在细菌对表面附着的反应中起着重要作用。本文就铜绿假单胞菌表面传感的分子机制和信号转导途径作一综述。
Aggregating and forming biofilms on biotic or abiotic surfaces are ubiquitous bacterial behaviors under various conditions. In clinical settings, persistent presence of biofilms increases the risks of healthcare-associated infections and imposes huge healthcare and economic burdens. Bacteria within biofilms are protected from external damage and attacks from the host immune system and can exchange genomic information including antibiotic-resistance genes. Dispersed bacterial cells from attached biofilms on medical devices or host tissues may also serve as the origin of further infections. Understanding how bacteria develop biofilms is pertinent to tackle biofilm-associated infections and transmission. Biofilms have been suggested as a continuum of growth modes for adapting to different environments, initiating from bacterial cells sensing their attachment to a surface and then switching cellular physiological status for mature biofilm development. It is crucial to understand bacterial gene regulatory networks and decision-making processes for biofilm formation upon initial surface attachment. Pseudomonas aeruginosa is one of the model microorganisms for studying bacterial population behaviors. Several hypotheses and studies have suggested that extracellular macromolecules and appendages play important roles in bacterial responses to the surface attachment. Here, I review recent studies on potential molecular mechanisms and signal transduction pathways for P. aeruginosa surface sensing.