Treatment of rhinitis medicamentosa with fluticasone propionate - an experimental study
Treatment of rhinitis medicamentosa with fluticasone propionate - an experimental study
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DOI：
10.1007/s004050000309
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发表时间：
2001-03-01
影响因子：
2.6
通讯作者：
Abdel-Salaam, S
中科院分区：
文献类型：
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作者：
Elwany, S;Abdel-Salaam, S
丙酸氟替卡松水性鼻喷雾剂（0.05% w/w）治疗药物性鼻炎的功效已在动物模型（豚鼠）中进行了研究。通过滴注 0.05% 硝酸萘唑啉（Privine）8周诱导药物性鼻炎。然后给动物施用丙酸氟替卡松鼻喷雾剂两周。该喷雾成功地清除了间质水肿，这是药物性鼻炎的病理标志。研究表明丙酸氟替卡松鼻喷雾剂对治疗药物性鼻炎患者有益。
The efficacy of fluticasone propionate aqueous nasal spray (0.05% w/w) in the treatment of rhinitis medicamentosa has been studied in an animal model (guinea pig) Rhinitis medicamentosa was induced through the instillation of 0.05% naphthazoline nitrate (Privine) for 8 weeks. Fluticasone propionate nasal spray was then administered to the animals for 2 weeks. The spray successfully cleared the interstitial edema which is the pathologic hallmark of rhinitis medicamentosa. The study suggests that fluticasone propionate nasal spray can be beneficial in the treatment of patients with rhinitis medicamentosa.