Organizing biochemistry in space and time using prion-like self-assembly.
Organizing biochemistry in space and time using prion-like self-assembly.
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DOI：
10.1016/j.coisb.2017.11.012
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发表时间：
2018-04
影响因子：
3.7
通讯作者：
Jarosz DF
中科院分区：
文献类型：
--
作者：
Jakobson CM;Jarosz DF
朊病毒样蛋白具有采用多种稳定构象的能力，其中至少一种可以从天然构象中招募蛋白质进入替代折叠。尽管典型的与疾病相关，朊病毒样组装最近被提出在空间和时间上组织一系列正常的生化过程。从细菌到哺乳动物的生物体都使用类似朊病毒的机制来（重新）组织它们的蛋白质组以响应细胞内和细胞外的刺激。朊病毒样行为是在系统水平上控制生物化学和基因调控的一种经济手段，朊病毒可以作为基于蛋白质的基因，促进诱导性状的准拉马克遗传。这些机制允许单个细胞使用相同的多肽补体表达不同的可遗传性状。因此，理解和控制朊病毒样行为是对抗各种疾病和组织工程生物系统的一种很有前途的策略。
Prion-like proteins have the capacity to adopt multiple stable conformations, at least one of which can recruit proteins from the native conformation into the alternative fold. Although classically associated with disease, prion-like assembly has recently been proposed to organize a range of normal biochemical processes in space and time. Organisms from bacteria to mammals use prion-like mechanisms to (re)organize their proteome in response to intracellular and extracellular stimuli. Prion-like behavior is an economical means to control biochemistry and gene regulation at the systems level, and prions can act as protein-based genes to facilitate quasi-Lamarckian inheritance of induced traits. These mechanisms allow individual cells to express distinct heritable traits using the same complement of polypeptides. Understanding and controlling prion-like behavior is therefore a promising strategy to combat diverse pathologies and organize engineered biological systems.