Normal function of the mushroom body defect gene of Drosophila is required for the regulation of the number and proliferation of neuroblasts.
Normal function of the mushroom body defect gene of Drosophila is required for the regulation of the number and proliferation of neuroblasts.
复制标题
果蝇蘑菇体缺陷基因的正常功能是调节神经母细胞数量和增殖所必需的。
DOI：
10.1006/dbio.1994.1034
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发表时间：
1994
影响因子：
2.7
通讯作者：
G. Technau
中科院分区：
文献类型：
--
作者：
A. Prokop;G. Technau
在果蝇发育中的中枢神经系统中，增殖遵循可重复且明确描述的空间和时间模式。这种模式涉及神经干细胞（神经母细胞）的确定数量和分布，以及这些神经母细胞分裂的精确调控的时间过程。我们发现蘑菇体缺陷（泥）基因的突变以相当特定的方式干扰这种模式的调节。在腹部神经元中，神经母细胞的一个子集延长了增殖期。额外的子细胞持续存在于成虫中。类似的缺陷也存在于前腹神经索和外侧中央脑区。然而，在蘑菇体皮层中，泥中的突变通过增加神经母细胞的数量来影响增殖模式。这些额外的神经母细胞根据其增殖时间进程及其后代的规格表现得与正常蘑菇体神经母细胞相似。
In the developing central nervous system of Drosophila, proliferation follows a reproducible and well-described spatial and temporal pattern. This pattern involves a defined number and distribution of neural stem cells (neuroblasts), as well as a precisely regulated time course of division of these neuroblasts. We show that mutations in the mushroom body defect (mud) gene interfere with the regulation of this pattern in a rather specific manner. In the abdominal neuromeres a subset of neuroblasts prolongs the period of proliferation. Additional daughter cells persist into the imago. Similar defects are expressed in the anterior ventral nerve cord and in the lateral central brain region. In the mushroom body cortex, however, mutations in mud affect the proliferation pattern by increasing the number of neuroblasts. These additional neuroblasts behave like normal mushroom body neuroblasts according to their time course of proliferation and the specification of their progeny.