Cognitive and functional changes with aging in schizophrenia
Cognitive and functional changes with aging in schizophrenia
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DOI：
10.1016/s0006-3223(99)00080-3
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发表时间：
1999-10-01
影响因子：
10.6
通讯作者：
Davis, KL
中科院分区：
文献类型：
--
作者：
Friedman, JI;Harvey, PD;Davis, KL
精神分裂症功能结局的变化似乎在晚年被夸大了，在年轻的精神分裂症患者中常见的认知和功能缺陷在某些情况下似乎在晚年恶化，而另一些患者似乎有稳定的病程而没有功能下降，还有一些患者据报道在晚年基本上没有残留症状。认知和功能缺陷似乎在终生严重功能缺陷的患者中更显着恶化。尽管这些患者存在严重的功能和认知缺陷，但神经病理学研究并未发现严重认知障碍的典型原因。本文回顾了目前对精神分裂症患者认知和功能变化的研究结果，特别关注终身功能结局不佳的患者，Biol Psychiatry 1999;46：921-928。(C)1999年生物精神病学学会。
The variation in functional outcome in schizophrenia appears to be exaggerated in late life, The cognitive and functional deficits commonly seen in younger schizophrenic patients appear to worsen in some cases in late life, while others patients appear to have a stable course of illness without functional decline, and still other patients have been reported to have essentially no residual symptoms in their later years. Cognitive and functional deficits appear to worsen more significantly in patients with a lifetime course of severe functional deficit. Despite the profound functional and cognitive deficits in these patients, neuropathologic studies have found no evidence of typical causes of severe cognitive impairments. This paper reviews the current findings on cognitive and functional changes in aging in schizophrenia, with a specific focus on patients with a poor lifetime functional outcome, Biol Psychiatry 1999;46:921-928. (C) 1999 Society of Biological Psychiatry.