Opioids in neuropathic pain.
Opioids in neuropathic pain.
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阿片类药物治疗神经性疼痛。
DOI：
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发表时间：
2005
影响因子：
3.1
通讯作者：
B. Przewłocka
中科院分区：
文献类型：
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作者：
R. Przewłocki;B. Przewłocka
阿片类药物对神经性疼痛缺乏有效的镇痛功效，尽管现在人们普遍认为这些药物的不良效果反映了其效力的降低。吗啡镇痛效力的降低被认为是由于神经损伤改变了阿片类药物系统或阿片类药物特异性信号传导的活性。内源性阿片类系统被发现存在于涉及伤害感受的区域，并与慢性疼痛有关。伤害性通路中的阿片肽生物合成和阿片受体密度及其功能在与脊髓损伤和周围神经损伤后的神经性疼痛相关的各种条件下发生变化。识别阿片类药物系统在神经性疼痛中的作用以及这些过程背后的分子和细胞机制对于理解阿片类药物在神经性疼痛中的作用非常重要，这将有望促进治疗策略的发展，从而提高阿片类药物缓解神经性疼痛的有效性。
Opiates lack potent analgesic efficacy in neuropathic pain although it is now generally accepted that the poor effect of these drugs reflects a reduction in their potency. Reduction of morphine antinociceptive potency was postulated to be due to the fact that nerve injury altered the activity of opioid systems or opioid specific signaling. Endogenous opioid systems were found to be represented in the regions involved in the nociception and are implicated in chronic pain. Opioid peptides biosynthesis and opioid receptors density in the nociceptive pathways and their functions change under various conditions associated with neuropathic pain following damage to the spinal cord and injury of peripheral nerves. Identification of a role of opioid systems in neuropathic pain and molecular and cellular mechanisms underlying these processes are of importance to understanding of the opioid action in neuropathic pain that will hopefully facilitate development of therapeutic strategies in which effectiveness of opioids in alleviation neuropathic pain is increased.