Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats
Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats
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DOI：
10.1016/s0042-6989(97)00341-6
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发表时间：
1998-05-01
期刊：
影响因子：
1.8
通讯作者：
Aguayo, AJ
中科院分区：
文献类型：
--
作者：
Clarke, DB;Bray, GM;Aguayo, AJ
通过重复注射或渗透微型泵给予玻璃体内 NT-4/5，轴突切除的 RGC 的存活率得到提高，但效果不如预期完全。与第 0 天单次注射神经营养蛋白相比，第 3 天或第 7 天的第二次注射仅在第 10 天维持了额外 10-20% 的 RGC。微型泵在 2 周时将 RGC 存活率提高了 4 倍 (50%)，但大多数 RGC 在 1 个月时消失了。因此，特定的神经营养蛋白可以在损伤后很快拯救许多 RGC，但长期神经元存活可能需要更好地了解神经营养蛋白受体的变化以及与其他分子的相互作用。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
The survival of axotomized RGCs was increased by intravitreal NT-4/5 given by repeated injections or osmotic minipumps, but the effects were less complete than predicted. Compared to a single injection of the neurotrophin on day 0, second injections on days 3 or 7 only sustained an additional 10-20% of the RGCs on day 10. Minipumps augmented RGC survival up to 4-fold (50%) at 2 weeks but most RGCs were lost by 1 month. Thus, specific neurotrophins can rescue many RGCs soon after injury but long-term neuronal survival may require a better understanding of changes in neurotrophin receptors and interactions with other molecules. (C) 1998 Elsevier Science Ltd. All rights reserved.