Overexpression of stathmin 1 confers an independent prognostic indicator in nasopharyngeal carcinoma
Overexpression of stathmin 1 confers an independent prognostic indicator in nasopharyngeal carcinoma
复制标题
DOI：
10.1007/s13277-013-1345-3
复制
发表时间：
2014-03-01
期刊：
影响因子：
--
通讯作者：
Shiue, Yow-Ling
中科院分区：
文献类型：
--
作者：
Hsu, Han-Ping;Li, Chien-Feng;Shiue, Yow-Ling
公共领域数据挖掘发现stathmin 1（STMN 1）转录本在鼻咽癌组织中的表达显著增高。也称为癌蛋白18，STMN 1在响应细胞条件调节细胞骨架的快速微管重塑中发挥重要作用。我们回顾性评估了124例连续的无远处转移的NPC患者的活检组织中STMN 1的免疫表达，并采用一致的指导方针进行治疗。结果与临床病理特征和患者生存率相关。结果表明，STMN 1高表达（50%）与高龄（p = 0.027）、较高的T分期（p = 0.003）和第7届美国癌症分期联合委员会的总体临床分期（p = 0.006）相关。在多变量分析中，STMN 1高表达是疾病特异性生存率（p = 0.001）、远端无转移生存率（p = 0.003）和局部无复发生存率（p = 0.006）较差的独立决定因素。E2 F转录因子1（E2 F1）或/和其二聚体伴侣转录因子Dp-1（TFDP 1）的外源表达显著诱导NPC衍生细胞系TW 01中的STMN 1蛋白水平。因此，高STMN 1蛋白水平通常与不利的趋化因子相关，并赋予NPC患者的肿瘤侵袭性，其上调可能归因于E2 F1和/或TFDP 1反式激活。
Data mining on public domain identified that stathmin 1 (STMN1) transcript was significantly higher expressed in nasopharyngeal carcinoma (NPC). Also known as the oncoprotein 18, STMN1 performs an important function in regulating rapid microtubule remodeling of the cytoskeleton in response to the cellular conditions. Immunoexpression of STMN1 was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The outcome was correlated with clinicopathological features and patient survivals. Results indicated that high STMN1 expressions (50 %) were correlated with advanced age (p = 0.027), higher T stage (p = 0.003), and overall clinical stage (p = 0.006) by the 7th American Joint Committee of Cancer Staging. In multivariate analyses, high STMN1 expression emerged as an independent prognosticator for worse disease-specific survival (p = 0.001), distal metastasis-free survival (p = 0.003), and local recurrence-free survival (p = 0.006). Exogenous expression of E2F transcription factor 1 (E2F1) or/and its dimeric partner, transcription factor Dp-1 (TFDP1), notably induced the STMN1 protein level in a NPC-derived cell line, TW01. Accordingly, high STMN1 protein level is commonly associated with adverse prognosticators and confers tumor aggressiveness in patients with NPC, and its upregulation might be attributed to E2F1 and/or TFDP1 transactivation.