ProRule: a new database containing functional and structural information on PROSITE profiles
ProRule: a new database containing functional and structural information on PROSITE profiles
复制标题
DOI：
10.1093/bioinformatics/bti614
复制
发表时间：
2005-11-01
期刊：
影响因子：
5.8
通讯作者：
Hulo, N
中科院分区：
文献类型：
--
作者：
Sigrist, CJA;De Castro, E;Hulo, N
动机：提高PROSITE图谱的鉴别能力，以促进功能测定，并提供有关图谱检测结构域的生物学相关信息，用于蛋白质的注释。概要：我们创建了一个新的数据库ProRule，其中包含有关PROSITE图谱的其他信息。ProRule特别包含结构和/或功能关键氨基酸的位置，以及它们必须满足以发挥其生物学作用的条件。这些补充数据应有助于UniProt Swiss-Prot知识库的功能确定和注释。ProRule还以Swiss-Prot行格式包含有关配置文件检测到的域的信息。因此，ProRule可用于使Swiss-Prot注释更加均匀和一致。ProRule的格式可以扩展以提供有关域组合的信息。
Motivation: Increase the discriminatory power of PROSITE profiles to facilitate function determination and provide biologically relevant information about domains detected by profiles for the annotation of proteins.Summary: We have created a new database, ProRule, which contains additional information about PROSITE profiles. ProRule contains notably the position of structurally and/or functionally critical amino acids, as well as the condition they must fulfill to play their biological role. These supplementary data should help function determination and annotation of the UniProt Swiss-Prot knowledgebase. ProRule also contains information about the domain detected by the profile in the Swiss-Prot line format. Hence, ProRule can be used to make Swiss-Prot annotation more homogeneous and consistent. The format of ProRule can be extended to provide information about combination of domains.