The rostromedial tegmental (RMTg) "brake" on dopamine and behavior: A decade of progress but also much unfinished work.
The rostromedial tegmental (RMTg) "brake" on dopamine and behavior: A decade of progress but also much unfinished work.
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DOI：
10.1016/j.neuropharm.2021.108763
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发表时间：
2021-10-15
影响因子：
4.7
通讯作者：
Jhou TC
中科院分区：
文献类型：
--
作者：
Jhou TC
Between 2005–2009, several research groups identified a strikingly dense inhibitory input to midbrain dopamine neurons in a previously uncharted region posterior to the ventral tegmental area (VTA). This region is now denoted as either the rostromedial tegmental nucleus (RMTg) or the “tail of the VTA” (tVTA), and is recognized to express distinct genetic markers, encode negative “prediction errors” (inverse to dopamine neurons), and play critical roles in behavioral inhibition and punishment learning. RMTg neurons are also influenced by many categories of abused drugs, and may drive some aversive responses to such drugs, particularly cocaine and alcohol. However, despite much progress, many important questions remain about RMTg molecular/genetic properties, diversity of projection targets, and applications to addiction, depression, and other neuropsychiatric disorders.
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发表时间：
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期刊：
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影响因子：
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