Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.
Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.
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25-羟基胆钙化醇向 1,25-二羟基胆钙化醇的肾脏转化的激素控制。
DOI：
10.1172/jci107065
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
D. Goodman
中科院分区：
文献类型：
--
作者：
H. Rasmussen;M. Wong;D. Bikle;D. Goodman
从缺乏维生素 D 的雏鸡中分离出的肾小管可在体外催化 25-羟基胆钙化醇转化为 1,25-二羟基胆钙化醇。这种转化由 5 x 10(-10) M 牛甲状旁腺激素或 10(-6) M 环 AMP 刺激。它被 10(-9) M 猪降钙素抑制。结论是，这些对肾激素 1,25-二羟基胆钙化醇合成的激素控制对于协调参与细胞外钙稳态的各个器官的活动具有特殊的生理意义。
Isolated renal tubules from vitamin D-deficient chicks catalyse the in vitro conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. This conversion is stimulated by 5 x 10(-10) M bovine parathyroid hormone, or by 10(-6) M cyclic AMP. It is inhibited by 10(-9) M porcine calcitonin. It is concluded that these hormonal controls of the synthesis of the renal hormone 1,25-dihydroxycholecalciferol are of particular physiological significance in coordinating the activities of the various organs involved in extracellular calcium homeostasis.