Portable and Eye-Safe Raman Spectroscopy for Point-of-Care Neurological Diagnostics
Portable and Eye-Safe Raman Spectroscopy for Point-of-Care Neurological Diagnostics
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用于护理点神经学诊断的便携式且人眼安全的拉曼光谱仪
DOI：
10.1117/12.2608249
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Harris G
中科院分区：
文献类型：
--
作者：
Harris G
拉曼光谱(RS)和机器学习被探索用于通过人眼快速、实时、灵敏地应用神经学诊断。使用内部构建的便携式RS系统获取脂肪猪组织和平板安装的猪视网膜样本的生化信息。RS和眼底成像已经与模眼模型相结合，在活体环境中获得了眼睛安全参数下的光谱，识别出高波数波段。该系统有可能检测到指示神经退行性疾病(如创伤性脑损伤)的急性生化变化，以便进行早期和准确的诊断，这对神经康复至关重要。
Raman Spectroscopy (RS) and machine learning are explored for the rapid, real-time, sensitive application of neurological diagnostics through the human eye. Biochemical information is obtained of fatty porcine tissue and flat-mounted porcine retinal samples using an in-house built, portable RS system. RS and FUNDUS imaging have been combined with a phantom eye model to obtain spectra under eye-safe parameters in an in-vivo environment, identifying high wavenumber bands. This system has the potential to detect acute, biochemical changes indicative of neurodegenerative disorders such as Traumatic Brain Injury for early and accurate diagnoses, crucial for neurological recovery.