Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus
Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus
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DOI：
10.4049/jimmunol.0901213
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发表时间：
2009-08-15
影响因子：
4.4
通讯作者：
Elewaut, Dirk
中科院分区：
文献类型：
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作者：
Drennan, Michael B.;Franki, Ann-Sophie;Elewaut, Dirk
目前用于定义T细胞从胸腺输出的模型表明，迁移的淋巴细胞作为功能成熟的细胞播种外周器官。该模型适用于从胸腺输出的大多数T细胞，除了不变的NK T（iNKT）细胞。iNKT细胞在阳性选择后经历谱系扩增，并在完全成熟后获得NK受体表达;然而，大多数成熟iNKT细胞通过尚未鉴定的机制保留在胸腺中。在这项研究中，我们证明，成熟的iNKT细胞保留在胸腺的趋化因子受体CXCR 3。我们认为CXCR 3配体在胸腺髓质上皮中的表达促进了成熟iNKT胸腺细胞的趋化性保留，并防止iNKT细胞渗漏到外周循环中。免疫学杂志，2009，183：2213-2216.
The current model used to define T cell export from the thymus suggests that emigrating lymphocytes seed the peripheral organs as functionally mature cells. This model holds true for the majority of T cells exported from the thymus with the exception of invariant NK T (iNKT) cells. iNKT cells undergo lineage expansion after positive selection and acquire NK receptor expression once fully mature; yet, the majority of mature iNKT cells are retained in the thymus by an as of yet unidentified mechanism. In this study we demonstrate that mature iNKT cells are retained in the thymus by the chemokine receptor CXCR3. We propose that the expression of CXCR3 ligands in the thymic medullary epithelium promotes the chemotactic retention of mature iNKT thymocytes and prevents leakage of iNKT cells into the peripheral circulation. The Journal of Immunology, 2009, 183: 2213-2216.