Electrospinning for bone tissue engineering.
Electrospinning for bone tissue engineering.
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DOI：
10.2174/187221008783478608
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发表时间：
2008
影响因子：
2
通讯作者：
K. Ramachandran;P. Gouma
中科院分区：
文献类型：
--
作者：
K. Ramachandran;P. Gouma
骨组织工程是一个非常有意义的研究领域，因为骨组织工程中存在大量的骨缺损，而现有技术在有效重建骨缺损方面存在一定的局限性。基于细胞的骨移植技术在克服目前使用的其他骨移植技术的局限性方面显示出了良好的前景。然而，这项技术的成功取决于合适的材料和加工路线的选择。生物可降解性、骨诱导性、高孔隙率和连通性以及机械稳定性是组织工程支架的一些重要要求。已经展示了几种制造生物支架的技术。然而，这些方法大多缺乏一步就能制备出具有复杂孔结构的三维支架的能力。静电纺丝是为了制备聚合物丝而发明的，最近已经成为制造骨组织工程生物支架的领先技术。该方法具有多功能性，可以生产具有所需形态和孔隙率的支架，以适应组织工程的需要。本文综述了近年来在静电纺丝和骨组织工程领域发布的一些专利。
Bone tissue engineering is a field of significant research interest owing to the large number of bone defects and the limitations in the present techniques to effectively reconstitute the defects. Cell-based bone graft technique has shown promise in overcoming the limitations of the other bone graft techniques currently used. However the success of this technique is dependent on the choice of appropriate material and processing route. Biodegradability, Osteoinductivity, High porosity with interconnected pores and mechanical stability are some of the important requirements for a tissue engineering scaffold. Several techniques have been demonstrated to fabricate bioscaffolds. However, most of these methods lack the capability to produce three dimensional scaffolds with complex pore structures in a single step. Electrospinning, invented to prepare polymeric threads, has recently emerged as a leading technique for fabricating bioscaffolds for bone tissue engineering. The process has the versatility to produce scaffolds with required morphology and porosity to suit the needs of tissue engineering. This paper reviews some of the recent patents issued in the field of electrospinning and bone tissue engineering.