Presence of α-Methyl-noradrenaline (‘Corbasil’) in the Heart of Guinea-pigs Treated with Metaraminol (‘Aramine’)
Presence of α-Methyl-noradrenaline (‘Corbasil’) in the Heart of Guinea-pigs Treated with Metaraminol (‘Aramine’)
复制标题
用间羟胺（“Aramine”）治疗的豚鼠心脏中存在 α-甲基去甲肾上腺素（“Corbasil”）
作者：
L. Maître;M. Staehelin
α-甲基-m-酪氨酸和α-甲基-多巴消耗心脏和大脑的内源性儿茶酚胺储存。内源性儿茶酚胺水平的下降似乎是由于这些氨基酸的代谢物的置换，特别是它们的脱羧和β-羟基化产物：间羟胺（“Aramine”）和α-甲基去甲肾上腺素（“Corbasil”），分别1-6。
α-METHYL-m-tyrosine and α-methyl-DOPA deplete endogenous catecholamine stores of heart and brain. The drop in endogenous catecholamine-levels appears to be due to a displacement by metabolites of these amino-acids and particularly by their decarboxylation and β-hydroxylation products: metaraminol (‘Aramine’) and α-methyl-noradrenaline (‘Corbasil’), respectively1–6.