An incremental mean first passage analysis for a quasistatic model of polymer translocation through a nanopore.
An incremental mean first passage analysis for a quasistatic model of polymer translocation through a nanopore.
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DOI：
10.1063/1.3580769
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发表时间：
2011-04
期刊：
影响因子：
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通讯作者：
H. D. de Haan;G. Slater
中科院分区：
文献类型：
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作者：
H. D. de Haan;G. Slater
对于聚合物通过纳米孔的移位，动力学的准静态假设产生了熵垒的易于处理的形式。虽然这是一个非常简化的模型，但有趣的功能，如强大的缩放，从其应用中出现。为了探索这些细节，我们提出了一种方法，映射的易位过程作为一个增量的平均首次通过问题。在这种方法中，感兴趣的量是聚合物在易位坐标s中实现Δs位移的平均第一时间t（0）。构建不同的初始条件和边界条件的情况下，解析和精确的数值方法被用来解决详细的动力学易位，并产生新的见解的熵障碍的性质。
For the translocation of a polymer through a nanopore, a quasistatic assumption for the dynamics yields a tractable form for the entropic barrier. Although this is a much simplified model, interesting features such as robust scaling emerge from its application. To explore these details, we present a method of mapping the translocation process as an incremental mean first passage problem. In this approach, the quantity of interest is the average first time t(0) at which the polymer achieves a displacement of Δs in the translocation coordinate s. Constructing scenarios with different initial conditions and boundary conditions, analytic and exact numerical approaches are used to resolve the dynamics of translocation in detail and generate new insight into the nature of the entropic barrier.