FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas.
FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas.
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DOI：
10.1007/s00259-017-3690-8
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发表时间：
2017-08
影响因子：
9.1
通讯作者：
Kluge R
中科院分区：
文献类型：
--
作者：
Barrington SF;Kluge R
利用18F-FDG对淋巴瘤患者进行治疗监测是目前临床上应用最广泛的方法之一。目前在治疗中使用PET/CT来评估化疗敏感性，根据临床实践中的“临时”PET给予成人和儿童霍奇金淋巴瘤的反应适应治疗。在移植前的环境中，PET也用于评估疾病的缓解和预测预后。关于侵袭性B细胞淋巴瘤的常见亚型，已有成熟的数据报道，最近的数据也支持使用PET来评估T细胞淋巴瘤的反应。在国际指南中，建议使用包含多维尔标准(DC)的多维尔五点量表进行反应评估。FDG摄取是根据正常纵隔和肝脏的参考区进行分级的。DC已在大多数淋巴瘤亚型中得到验证。DC允许根据临床背景或研究问题调整适当或不充分反应的阈值。对于PET读者来说，了解DC如何应用于反应适应试验，以便与多学科团队进行正确的解释和讨论，这一点很重要。还开发了以标准化方式进行正电子发射计算机断层扫描的定量方法，这可能会进一步改善反应评估，包括对DC(QpET)的定量扩展。这在提供一个连续的量表以细化在特定临床情况下的适当/不充分反应的阈值或在试验中优化治疗方面可能具有优势。QpET对观察者的依赖程度也较低，并限制了由于背景活动的影响而造成的光学误解问题。
PET using 18F-FDG for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. PET/CT is nowadays used during treatment to assess chemosensitivity, with response-adapted therapy given according to ‘interim’ PET in clinical practice to adults and children with Hodgkin lymphoma. PET is also used to assess remission from disease and to predict prognosis in the pretransplant setting. Mature data have been reported for the common subtypes of aggressive B-cell lymphomas, with more recent data also supporting the use of PET for response assessment in T-cell lymphomas. The Deauville five-point scale incorporating the Deauville criteria (DC) is recommended for response assessment in international guidelines. FDG uptake is graded in relation to the reference regions of normal mediastinum and liver. The DC have been validated in most lymphoma subtypes. The DC permit the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. It is important for PET readers to understand how the DC have been applied in response-adapted trials for correct interpretation and discussion with the multidisciplinary team. Quantitative methods to perform PET in standardized ways have also been developed which may further improve response assessment including a quantitative extension to the DC (qPET). This may have advantages in providing a continuous scale to refine the threshold for adequate/inadequate response in specific clinical situations or treatment optimization in trials. qPET is also less observer-dependent and limits the problem of optical misinterpretation due to the influence of background activity.
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影响因子：
9.3
作者：
Carr, Robert;Fanti, Stefano;Dondi, Maurizio
通讯作者：
Dondi, Maurizio
影响因子：
9.3
作者：
Cerci, Juliano J.;Pracchia, Luis F.;Meneghetti, Jose C.
通讯作者：
Meneghetti, Jose C.
影响因子：
50.5
作者：
Barrington, S. F.;MacKewn, J. E.;O'Doherty, M. J.
通讯作者：
O'Doherty, M. J.
影响因子：
50.5
作者：
Barnes, J. A.;LaCasce, A. S.;Abramson, J. S.
通讯作者：
Abramson, J. S.
DOI：
10.1016/s0936-6555(05)80549-7
发表时间：
1995-01-01
期刊：
Clinical oncology (Royal College of Radiologists (Great Britain))
影响因子：
--
作者：
Barrington, S F;Carr, R
通讯作者：
Carr, R