A potential role of microRNAs in plant response to metal toxicity.
A potential role of microRNAs in plant response to metal toxicity.
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DOI：
10.1039/c3mt00022b
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发表时间：
2013-08
期刊：
影响因子：
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通讯作者：
Z. Yang;Jing Chen
中科院分区：
文献类型：
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作者：
Z. Yang;Jing Chen
microRNAs（miRNAs）通过在转录后水平沉默基因表达来调控植物的生长发育。最近的研究表明，miRNAs是植物对环境胁迫反应的调节因子。此外，小RNA的全基因组分析显示，许多miRNA对重金属有反应。对金属调控的miRNAs的靶基因的鉴定表明，大多数靶基因参与多种代谢途径，包括硫酸盐分配和同化、植物激素信号传导、抗氧化和miRNAs生物合成。因此，小RNA的高通量测序为挖掘植物中响应于金属胁迫的许多已知和未知的miRNA提供了强有力的工具。在这里，我们讨论了最近的研究集中在新发现的miRNAs及其在植物中的潜在目标，并提出了一个新的方案，涉及植物耐受金属毒性的动态网络的一部分，定义了miRNAs在植物适应重金属胁迫的潜在作用。
MicroRNAs (miRNAs) regulate plant growth and development by silencing gene expression at post-transcriptional level. Recent studies have shown that miRNAs are the regulators of plant response to environmental stresses. Also, genome-wide profiling of small RNAs reveals that many miRNAs are in response to heavy metals. Identification of the targets of metal-regulated miRNAs demonstrated that most of the target genes are involved in diverse metabolic pathways including sulphate allocation and assimilation, phytohormone signalling, antioxidation, and miRNA biogenesis. Thus, the high-throughput sequencing of small RNAs provides a powerful tool for mining a number of known and unknown miRNAs in plants in response to metal stress. Here, we discuss recent studies focusing on the newly identified miRNAs and their potential targets in plants and propose a new scenario involving plant tolerance to metal toxicity as part of the dynamic network that defines the potential roles of miRNAs in plant adaptation to heavy metal stress.