Primary immunodeficiency diseases: an update
Primary immunodeficiency diseases: an update
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DOI：
10.1046/j.1365-2249.2003.02110.x
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发表时间：
2003-04-01
影响因子：
4.6
通讯作者：
Rosen, F
中科院分区：
文献类型：
--
作者：
Chapel, H;Geha, R;Rosen, F
IUIS原发性免疫缺陷[PID]科学委员会的最后一份完整报告于3年前发表在《临床和实验免疫学》杂志上。这涵盖了相关的基本免疫学原理，细胞，遗传，体液（包括细胞因子）和诱导方面的免疫反应，这些微生物抗原参与人类感染。所有主要的免疫缺陷（和诊断所需的调查）依次讨论，从T和B细胞的联合缺陷，主要是体液缺陷，T细胞缺陷（包括细胞因子和细胞因子受体的生产），补体和吞噬细胞缺陷和相关系统中的遗传缺陷相关的免疫缺陷。关于治疗和继发性免疫缺陷原因的简要描述的一节完成了当时已知的ID的知识。该报告是及时的，并已在文献中被大量引用，作为PID疾病及其治疗机制论文的参考点。引文索引必须是实质性的。该委员会最近一次会议于2001年7月举行。在此期间的2年中，几乎没有新类型的PID;大多数新描述的疾病是当前表型的扩展，例如：
The last full report of the IUIS Scientific Committee for Primary Immunodeficiencies [PIDs] was published in Clinical and Experimental Immunology over 3 years ago [1]. This covered the relevant basic immunological principles, cellular, genetic, humoral (including cytokine) and induction aspects of immune responses to those microbial antigens involved in human infections. All primary immunodeficiencies (and the investigations required for diagnosis) are discussed in turn, ranging from combined deficiencies of T and B cells, predominantly humoral defects, T cell defects (including those of cytokine and cytokine receptor production), complement and phagocyte deficiencies and those immunodeficiencies associated with genetic defects in related systems. A section on therapies and brief descriptions of causes of secondary immunodeficiencies completed the knowledge of ID known at that time.The report was timely and has been much quoted in the literature as a reference point for papers on mechanisms of both PID diseases and their treatments. The citation index must be substantial. The most recent meeting of this committee took place in July 2001. During the intervening 2 years there were few new types of PID; most of the newly described diseases were extensions of current phenotypes such as: