Fish consumption and risk of stroke in men
Fish consumption and risk of stroke in men
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DOI：
10.1001/jama.288.24.3130
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发表时间：
2002-12-25
影响因子：
120.7
通讯作者：
Ascherio, A
中科院分区：
文献类型：
--
作者：
He, K;Rimm, EB;Ascherio, A
研究目的：探讨鱼类摄入量和长链ω-3多不饱和脂肪酸（PUFA）摄入量与男性中风风险之间的关系。设计和设置健康专业随访研究，一项随访12年的美国前瞻性队列研究-参与者共有43671名年龄在40至75岁之间的男性，他们完成了详细和有效的半定量食物频率问卷，并且在基线时没有心血管疾病结果在12年的随访期间，我们记录了608例中风，包括377例缺血性中风，106例出血性中风和125例未分类的中风。与每月吃鱼少于一次的男性相比，每月吃鱼1 - 3次的男性缺血性卒中的多变量RR显著较低（RR，0.57; 95%置信区间[Cl]，0.35-0.95）。然而，较高的鱼类摄入频率与进一步降低风险无关;对于每周食用5次或更多次鱼类的男性，RR为0.54（95%CI，0.31-0.94）。样条分析证实了这种线性的缺乏。通过对鱼类摄入量进行二分，与每月吃鱼少于一次的男性相比，每月至少吃一次鱼类的男性缺血性卒中的多变量RR为0.56（95%CI，0.38-0.83），出血性卒中为1.36（95%CI，0.48-3.82）。鱼类摄入量与缺血性中风风险之间的负相关性并没有因使用阿司匹林而发生实质性改变。鱼或长链omega-3多不饱和脂肪酸摄入量和出血性stroke. Conclusion的风险之间没有显着的关联，我们的研究结果表明，吃鱼每月一次或更多可以降低男性缺血性中风的风险。
Context The effect of fish consumption or long-chain omega-3 polyunsaturated fatty acid (PUFA) intake on risk of stroke remains uncertain.Objective To examine the relation of fish consumption and long-chain omega-3 PUFA intake and risk of stroke in men.Design and Setting The Health Professional Follow-up Study, a US prospective cohort study with 12 years of follow-up.Participants A total of 43 671 men aged 40 to 75 years who completed a detailed and validated semiquantitative food frequency questionnaire and who were free of cardiovascular disease at baseline in 1986.Main Outcome Measure Relative risk (RR) of stroke by subtype based on cumulative average fish consumption or long-chain omega-3 PUFA intake, ascertained in 1986, 1990, and 1994.Results We documented 608 strokes during the 12-year follow-up period, including 377 ischemic, 106 hemorrhagic, and 125 unclassified strokes. Compared with men who consumed fish less than once per month, the multivariate RR of ischemic stroke was significantly lower among those who ate fish 1 to 3 times per month (RR, 0.57; 95% confidence interval [Cl], 0.35-0.95). However, a higher frequency of fish intake was not associated with further risk reduction; the RR was 0.54 (95% Cl, 0.31-0.94) for men who consumed fish 5 or more times per week. This lack of linearity was confirmed by spline analyses. By dichotomized fish intake, the multivariate RR for men who consumed fish at least once per month compared with those who ate fish less than once per month was 0.56 (95% Cl, 0.38-0.83) for ischemic stroke and 1.36 (95% Cl, 0.48-3.82) for hemorrhagic stroke. The inverse association between fish intake and risk of ischemic stroke was not materially modified by use of aspirin. No significant associations were found between fish or long-chain omega-3 PUFA intake and risk of hemorrhagic stroke.Conclusion Our findings suggest that eating fish once per month or more can reduce the risk of ischemic stroke in men.