Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data.
Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data.
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DOI：
10.3233/jpd-160912
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
all NPF-QII Investigators
中科院分区：
文献类型：
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作者：
Rafferty MR;Schmidt PN;Luo ST;Li K;Marras C;Davis TL;Guttman M;Cubillos F;Simuni T;all NPF-QII Investigators
基于研究的运动干预改善帕金森病（PD）患者的健康相关生活质量（HRQL）和活动能力。研究运动习惯是否与两年来HRQL和活动性的变化相关。我们确定了一组国家帕金森基金会质量改进计划（NPF-QII）的参与者，进行了三次访问。使用帕金森病问卷（PDQ-39）和定时起床和行走（TUG）测量HRQL和活动性。我们比较了自我报告的定期锻炼者（≥2.5小时/周）与每周不锻炼2.5小时的人。然后，我们使用混合效应回归模型，量化了与运动增加30分钟相关的HRQL和活动性的变化。有3次观察性研究访视的参与者（n = 3408）比访视次数较少的参与者更年轻，PD更轻。2年后，坚持锻炼者和在基线访视后开始定期锻炼的人的HRQL和活动性下降幅度小于不锻炼者（p < 0.05）。不锻炼的人在PDQ-39上每年恶化1.37分，在TUG上每年恶化0.47秒。每周增加30分钟的运动量与HRQL（-0.16分）和移动性（-0.04秒）的缓慢下降有关。运动对HRQL的益处在晚期PD中（-0.41分）大于轻度PD（-0.14分; p < 0.02）。在基线后持续锻炼和开始定期锻炼与HRQL和两年活动性变化的小但显著的积极影响相关。运动与HRQL在晚期PD中的更大关联支持在晚期PD中改善运动的鼓励和促进。
Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson’s disease (PD). To examine whether exercise habits were associated with changes in HRQL and mobility over two years. We identified a cohort of National Parkinson Foundation Quality Improvement Initiative (NPF-QII) participants with three visits. HRQL and mobility were measured with the Parkinson’s Disease Questionnaire (PDQ-39) and Timed Up and Go (TUG). We compared self-reported regular exercisers (≥2.5 hours/week) with people who did not exercise 2.5 hours/week. Then we quantified changes in HRQL and mobility associated with 30-minute increases in exercise, across PD severity, using mixed effects regression models. Participants with three observational study visits (n = 3408) were younger, with milder PD, than participants with fewer visits. After 2 years, consistent exercisers and people who started to exercise regularly after their baseline visit had smaller declines in HRQL and mobility than non-exercisers (p < 0.05). Non-exercisers worsened by 1.37 points on the PDQ-39 and a 0.47 seconds on the TUG per year. Increasing exercise by 30 minutes/week was associated with slower declines in HRQL (−0.16 points) and mobility (−0.04 sec). The benefit of exercise on HRQL was greater in advanced PD (−0.41 points) than mild PD (−0.14 points; p < 0.02). Consistently exercising and starting regular exercise after baseline were associated with small but significant positive effects on HRQL and mobility changes over two years. The greater association of exercise with HRQL in advanced PD supports improving encouragement and facilitation of exercise in advanced PD.