SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGING OF THE CHORIOCAPILLARIS
SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGING OF THE CHORIOCAPILLARIS
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DOI：
10.1097/iae.0000000000003109
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发表时间：
2021-07-01
影响因子：
3.3
通讯作者：
Spaide, Richard F.
中科院分区：
文献类型：
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作者：
Ledesma-Gil, Gerardo;Fernandez-Avellaneda, Pedro;Spaide, Richard F.
目的：分析蔡司PLEX Elite 9000默认位置上下不同深度的扫描源光学相干血管造影图像。方法：对20、30岁被试正常眼进行评价。血管造影板图像在视网膜色素上皮以下29 μ m至49 μ m的默认位置，以及以下21 μ m至41 μ m至52 μ m至72 μ m的位置逐级拍摄。使用设备软件中的投影去除功能对图像进行处理。对原始图像进行了评估，同时对经过公布的补偿技术的图像进行了评估，该技术调整了对采样层的光穿透。结果：对11名受试者的11只眼进行了未补偿和补偿后的投影去除功能关闭和打开的评估。默认位置在视网膜色素上皮下方29 ~ 49 μ m，可见颗粒状的绒毛膜毛细血管外观。这种现象在每一组的所有石板中都存在，在深度上略有不同。投影去除函数对覆盖的视网膜血管的灰度值进行了修改，减小了投影。补偿技术改变了流亏的外观，并且在打开投影去除功能时，其引起的变化在图像上更加明显。结论：不同水平绒毛膜的扫描源光学相干血管造影血流图像在外观上相似，提示绒毛膜的投影在图像形成中很重要，尽管绒毛膜内的血管层可能有不同程度的贡献。一个模型解释突出的投影伪影观察到脉络膜扫描源光学相干血管造影成像提出。
Purpose: To analyze swept-source optical coherence angiography images acquired at different depths above and below the default location of the Zeiss PLEX Elite 9000. Methods: Normal eyes of subjects in their 20s and 30s were evaluated. Angiographic slab images were taken at the default location of 29 mu m to 49 mu m below the retinal pigment epithelium and 21 mu m to 41 mu m through 52 mu m to 72 mu m below in steps. The images were processed using the projection removal function from the device's software. Raw images were evaluated, as were images that underwent a published compensation technique that adjusts for light penetration to the sampled layer. Results: Eleven eyes of 11 subjects were evaluated for the uncompensated and the compensated sets with the projection removal function turned off and on. The default location, 29 mu m to 49 mu m below the retinal pigment epithelium, showed a granular choriocapillaris appearance. This appearance remained in all slabs from each group, differing slightly throughout depth. The projection removal function modified the grayscale values and diminished projection from overlaying retinal vessels. The compensation technique altered the appearance of flow deficits, and the changes induced by it were more evident on the images were the projection removal function was turned on. Conclusion: Flow images in swept-source optical coherence angiography of the choriocapillaris from varying levels are similar in appearance, suggesting projection from the choriocapillaris is important in image formation, although layers of vessels in the inner choroid may contribute by various amounts. A model explaining the prominent projection artifacts observed in the choroid with swept-source optical coherence angiography imaging is presented.