Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia
Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia
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DOI：
10.12659/msm.881768
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发表时间：
2011-05-01
影响因子：
3.1
通讯作者：
Bielanska, Anna
中科院分区：
文献类型：
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作者：
Cechnicki, Andrzej;Hanuszkiewicz, Igor;Bielanska, Anna
背景：这项预后研究的目的是调查未经治疗的精神病(DUP)持续时间是否对疾病的进一步病程具有预后价值。材料/方法：58例(原始研究组的77%)被诊断为DSM III型精神分裂症，后来又被DSM IV T-R重新诊断，在4个时间点进行评估。在1年、3年、7年和12年的随访中评估复发次数、住院治疗的平均时间、再次住院的次数和精神病理症状的严重程度。DUP信息通过与患者及其家属的临床访谈获得。结果：DUP持续时间越长，复发数增加越明显(P
Background: The goal of this prognostic study was to investigate whether the duration of untreated psychosis (DUP) may have a prognostic value with regard to the further course of the illness.Material/Methods: Fifty-eight patients (77% of the original study group) diagnosed with DSM III schizophrenia and later re-diagnosed with DSM IV T-R were assessed at 4 time points. Number of relapses, average time of inpatient treatment, number of inpatient readmissions, and severity of psychopathological symptoms were assessed at 1-, 3-, 7- and 12-year follow-ups. DUP information was obtained by clinical interview with patients and their families. The severity of symptoms was assessed using BPRS-SA, UCLA version.Results: Increases in the number of relapses at follow-ups were more prominent in the group with a longer DUP (p