Fast MR Parameter Mapping Using k-t Principal Component Analysis
Fast MR Parameter Mapping Using k-t Principal Component Analysis
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DOI：
10.1002/mrm.22826
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发表时间：
2011-09-01
影响因子：
3.3
通讯作者：
Breuer, Felix A.
中科院分区：
文献类型：
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作者：
Petzschner, Frederike H.;Ponce, Irene P.;Breuer, Felix A.
磁共振参数的量化在临床应用中起着越来越重要的作用，例如神经退行性疾病的检测和分类。其在临床常规中广泛使用的主要障碍是扫描时间长。因此，非常需要允许扫描时间显著减少的策略。最近，k-t主成分分析方法被引入用于动态心脏成像以加速数据采集。这是通过对k-t空间进行欠采样并基于k-t广泛使用的线性采集加速技术（BLAST）概念和预定的时间基函数来约束混叠数据的重构来完成的。本研究的目的是调查的k-t主成分分析的概念是否可以适应参数量化，特别是允许显着加速反转恢复快速成像与稳态进动（TrueFISP）采集。我们发现，三个基函数和中央k空间中的单个训练数据线足以实现量化测量的8倍加速。这允许在仅6 s内以亚毫米平面内分辨率在一个切片中估计弛豫时间T-1和T-2以及自旋密度。我们的研究结果表明，k-t主成分分析方法是一个潜在的候选人，使采集时间的磁共振参数映射到临床上可接受的水平。Magn Reson Med 66：706-716，2011.（C）2011 Wiley-Liss，Inc.
Quantification of magnetic resonance parameters plays an increasingly important role in clinical applications, such as the detection and classification of neurodegenerative diseases. The major obstacle that remains for its widespread use in clinical routine is the long scanning times. Therefore, strategies that allow for significant decreases in scan time are highly desired. Recently, the k-t principal component analysis method was introduced for dynamic cardiac imaging to accelerate data acquisition. This is done by undersampling k-t space and constraining the reconstruction of the aliased data based on the k-t Broad-use Linear Acquisition Speed-up Technique (BLAST) concept and predetermined temporal basis functions. The objective of this study was to investigate whether the k-t principal component analysis concept can be adapted to parameter quantification, specifically allowing for significant acceleration of an inversion recovery fast imaging with steady state precession (TrueFISP) acquisition. We found that three basis functions and a single training data line in central k-space were sufficient to achieve up to an 8-fold acceleration of the quantification measurement. This allows for an estimation of relaxation times T-1 and T-2 and spin density in one slice with sub-millimeter in-plane resolution, in only 6 s. Our findings demonstrate that the k-t principal component analysis method is a potential candidate to bring the acquisition time for magnetic resonance parameter mapping to a clinically acceptable level. Magn Reson Med 66:706-716, 2011. (C)2011 Wiley-Liss, Inc.