Oxidative stress, aging, and diseases.
Oxidative stress, aging, and diseases.
复制标题
DOI：
10.2147/cia.s158513
复制
发表时间：
2018
影响因子：
3.6
通讯作者：
Abete P
中科院分区：
文献类型：
--
作者：
Liguori I;Russo G;Curcio F;Bulli G;Aran L;Della-Morte D;Gargiulo G;Testa G;Cacciatore F;Bonaduce D;Abete P
活性氧和氮(RON)是由几个内源和外源过程产生的，它们的负面影响被抗氧化防御中和。氧化应激是由于RONS的产生和这些抗氧化剂防御之间的不平衡造成的。衰老是以组织和器官功能的进行性丧失为特征的过程。衰老的氧化应激理论是基于这样一种假设，即与年龄相关的功能丧失是由于RONS诱导的损伤的积累。与此同时，氧化应激与几种与年龄相关的疾病(如心血管疾病、慢性阻塞性肺疾病、慢性肾脏疾病、神经退行性疾病和癌症)有关，包括骨质疏松症和虚弱。不同类型的氧化应激生物标志物已被确定，并可能提供有关治疗效果的重要信息，指导患者选择最有效的药物/剂量方案，如果从病理生理学的角度来看特别相关，则作用于特定的治疗靶点。鉴于氧化应激在许多临床症状和衰老的发病机制中的重要作用，抗氧化治疗可能会对几种疾病的自然病程产生积极影响，但需要进一步的研究来评估这些治疗干预的真正效果。这篇论文的目的是提供关于这一日益感兴趣的复杂主题的文献综述。
Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty. Different types of oxidative stress biomarkers have been identified and may provide important information about the efficacy of the treatment, guiding the selection of the most effective drugs/dose regimens for patients and, if particularly relevant from a pathophysiological point of view, acting on a specific therapeutic target. Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions. The purpose of this paper is to provide a review of literature on this complex topic of ever increasing interest.