Monitoring and switching of cortico-basal ganglia loop functions by the thalamo-striatal system
Monitoring and switching of cortico-basal ganglia loop functions by the thalamo-striatal system
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DOI：
10.1016/j.neures.2003.12.002
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发表时间：
2004-04-01
影响因子：
2.9
通讯作者：
Hori, Y
中科院分区：
文献类型：
--
作者：
Kimura, M;Minamimoto, T;Hori, Y
最近的生理和束追踪研究揭示了中央正中核和束旁核（CM-Pf复合体）（丘脑后层内核（ILN））与基底神经节回路的紧密耦合。这些核先前被归类为上行网状丘脑皮质激活系统的一部分，对单个神经元活动和神经元活动中断的研究表明，它们参与感觉事件驱动的注意力和唤醒过程，特别是在不可预测事件或与预测相反的事件的背景下。在本文中，我们提出了一个假设模型，设想 CM-Pf 复合体根据外部事件的可预测性以两种不同的模式发挥作用，即一种用于通过皮质基底神经节环路系统监控“自上而下”的偏置控制，以选择行动和认知信号，另一种用于根据显着外部事件的信号从偏置控制切换到“自下而上”的控制。该模型提供了对 CM-Pf 复合体功能的新见解，应该有助于更好地理解这一重要的大脑系统。 (C) 2003 Elsevier Ireland Ltd 和日本神经科学学会。版权所有。
Recent physiological and tract tracing studies revealed tight coupling of the centre median and parafascicular nuclei (the CM-Pf complex), which are posterior intralaminar nuclei (ILN) of the thalamus, with basal ganglia circuits. These nuclei have previously been classified as part of the ascending reticulo-thalamo-cortical activating system, with studies of single neuron activity and of interruption of neuronal activity suggested that they participate in the processes of sensory event-driven attention and arousal, particularly in the context of unpredicted events or events contrary to predictions. In this article, we propose a hypothetical model that envisions that the CM-Pf complex functions in two different modes depending on the predictability of external events, i.e., one for monitoring 'top-down' biased control through the cortico-basal ganglia loop system for selecting signals for action and cognition and the other for switching from biased control to 'bottom-up' control based on the signals of salient external events. This model provides a new insight into the function of the CM-Pf complex and should lead to a better understanding of this important brain system. (C) 2003 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.