Abnormal brain connectivity in children after early severe socioemotional deprivation:: A diffusion tensor imaging study
Abnormal brain connectivity in children after early severe socioemotional deprivation:: A diffusion tensor imaging study
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DOI：
10.1542/peds.2005-1727
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发表时间：
2006-06-01
期刊：
影响因子：
8
通讯作者：
Makki, Malek
中科院分区：
文献类型：
--
作者：
Eluvathingal, Thomas J.;Chugani, Harry T.;Makki, Malek
目标。我们之前曾报道，在罗马尼亚孤儿院接受早期社会情绪剥夺的儿童显示，边缘和边缘旁结构中的葡萄糖代谢不足，包括眼眶额叶回、边缘下前额叶皮质、海马体/杏仁体、外侧颞叶皮质和脑干。方法：对7名有早期严重社会情绪剥夺史的右利手儿童(5名女孩和2名男孩；平均年龄：9.7±-2.6岁)和7名右利手正常儿童(4名女孩和3名男孩)的钩状束、终纹、穹隆和扣带的各向异性和表观扩散系数进行了测量，并与7名右利手正常儿童(4名女孩和3名男孩；平均年龄：10.7+/-2.8岁)。结果：对孤儿的神经心理学评估证实了相对较轻的特定认知障碍和冲动，这与先前对罗马尼亚孤儿院收养的儿童的研究一致。早期剥夺组大鼠左侧钩束各向异性分数明显低于对照组。在所有测量的神经束中，早期剥夺组的表观扩散系数值倾向于大于对照组，但没有达到统计学意义。结论：我们的研究表明，在经历了社会情绪剥夺的儿童中，左侧钩状束的结构发生了变化，这可能是这些儿童普遍存在的认知、社会情感和行为困难的部分原因。
OBJECTIVES. We previously reported that children who were subjected to early socioemotional deprivation in Romanian orphanages showed glucose hypometabolism in limbic and paralimbic structures, including the orbital frontal gyrus, infralimbic prefrontal cortex, hippocampus/amygdala, lateral temporal cortex, and the brainstem. The present study used diffusion tensor imaging tractography to examine the integrity of white matter tracts that connect these brain regions.METHODS. Fractional anisotropy and apparent diffusion coefficient for uncinate fasciculus, stria terminalis, fornix, and cingulum were measured in 7 right-handed children (5 girls and 2 boys; mean age: 9.7 +/- 2.6 years) with a history of early severe socioemotional deprivation in Eastern European orphanages and compared with similar measurements in 7 right-handed normal children (4 girls and 3 boys; mean age: 10.7 +/- 2.8 years).RESULTS. Neuropsychological assessment of the orphans verified the relatively mild specific cognitive impairment and impulsivity consistent with previous studies of children who were adopted from Romanian orphanages. Fractional anisotropy values in the left uncinate fasciculus were decreased significantly in the early deprivation group compared with control subjects. Apparent diffusion coefficient values for the early deprivation group tended to be greater than that in control subjects in all of the tracts measured, without reaching statistical significance.CONCLUSION. Our study demonstrates in children who experienced socioemotional deprivation a structural change in the left uncinate fasciculus that partly may underlie the cognitive, socioemotional, and behavioral difficulties that commonly are observed in these children.