Prospective study of serum selenium levels and incident esophageal and gastric cancers
Prospective study of serum selenium levels and incident esophageal and gastric cancers
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DOI：
10.1093/jnci/92.21.1753
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发表时间：
2000-11-01
期刊：
影响因子：
--
通讯作者：
Taylor, PR
中科院分区：
文献类型：
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作者：
Mark, SD;Qiao, YL;Taylor, PR
背景：从1986年3月到1991年5月，我们在中国林县进行了一项随机营养干预试验，即普通人群试验。林县是一个鳞状食管癌和胃贲门腺癌流行的地区。我们发现，接受硒、β -胡萝卜素和维生素E的参与者癌症死亡率明显低于未接受者。在当前研究中，我们检测了参与者在试验前（1985年）血清中测得的硒水平与试验期间患鳞状食管癌、胃贲门癌和胃非贲门癌的后续风险之间的关系。
方法：本研究根据分层病例 - 队列抽样方案进行设计和分析，六个分层由性别和三个年龄类别定义。我们测量了590例食管癌患者、402例胃贲门癌患者和87例胃非贲门癌患者以及1062例对照受试者的血清硒水平。基于考克斯比例风险模型估计癌症的相对风险（RRs）、绝对风险和人群归因风险。所有统计检验均为双侧检验。
结果：我们发现血清硒水平与食管癌发病率呈极显著负相关（趋势P值……（此处原文未完整给出趋势P值相关的完整内容））
Background: From March 1986 through May 1991, we conducted a randomized nutritional intervention trial, the General Population Trial, in Linxian, China, a region with epidemic rates of squamous esophageal and adenomatous gastric cardia cancers, We found that participants who received selenium, beta -carotene, and vitamin E had significantly lower cancer mortality rates than those who did not. In the current study, we examined the relationship between selenium levels measured in pretrial (1985) sera from participants and the subsequent risk of developing squamous esophageal, gastric cardia, and gastric non-cardia cancers during the trial. Methods: This study was designed and analyzed in accord with a stratified case-cohort sampling scheme, with the six strata defined by sex and three age categories. We measured serum selenium levels in 590 case subjects with esophageal cancer, 402 with gastric cardia cancers, and 87 with gastric non-cardia cancers as well as in 1062 control subjects. Relative risks (RRs), absolute risks, and population attributable risk for cancers were estimated on the basis of the Cox proportional hazards models. All statistical tests are two-sided. Results: We found highly significant inverse associations of serum selenium levels with the incidence of esophageal (P for trend