Experimental lumbar spondylolisthesis in growing rabbits.
Experimental lumbar spondylolisthesis in growing rabbits.
复制标题
生长中兔子的实验性腰椎滑脱。
DOI：
10.1097/00003086-199611000-00035
复制
发表时间：
1996
影响因子：
4.2
通讯作者：
H. Osterman
中科院分区：
文献类型：
--
作者：
K. Osterman;H. Osterman
腰骶椎滑脱症是通过在L7-S1节段切除双侧小关节在生长中的兔子实验引起的。测试了用骨水泥额外固定L 6-L7节段和切断腰骶椎间盘对滑脱发展的影响。小关节切除后平均腹侧滑动21%。这种滑脱类似于在人类中观察到的脊椎滑脱，表现为滑脱椎体楔入、骶骨变圆和矢状旋转增加。结合小关节切除和L 6-L7节段的固定，导致平均滑动15%。滑脱的形态特征与平面小关节切除后所见相似。小关节切除联合腰骶椎间盘切除后，结果有所不同。平均滑动率仅为6%，骶骨变圆是一个突出的特征。这个实验表明，脊柱的直立姿势不是脊椎前移发展的先决条件。一只生长中的兔子的双侧小关节切除导致了类似人类的脊椎前移。这一模型为进一步的实验研究提供了依据。
Lumbosacral spondylolisthesis was provoked experimentally in growing rabbits by means of a bilateral facet joint resection at the L7-S1 segment. The effects of additional immobilization of the L6-L7 segment with bone cement and of severing the lumbosacral disc on the development of the olisthesis were tested. A mean ventral slip of 21% was seen after the facet joint resection. The slip resembled the spondylolisthesis seen in humans in wedging of the olisthetic vertebra, sacral rounding, and increased sagittal rotation. Combining the facet joint resection with immobilization of the L6-L7 segment resulted in a mean slip of 15%. Morphologic features of the slip were like those seen after a plain facet joint resection. A different result was seen after facet joint resection was combined with severing of the lumbosacral disc. The mean slip was only 6%, and sacral rounding was a prominent feature. This experiment shows that an upright posture of the spine is not a prerequisite for the development of spondylolisthesis. A bilateral facet joint resection in a growing rabbit results in a human like spondylolisthesis. This model may help further experimental studies concerning the changes in the olisthetic disc.