Towards a molecular understanding of human diseases using Dictyostelium discoideum.
Towards a molecular understanding of human diseases using Dictyostelium discoideum.
复制标题
使用盘基网柄菌对人类疾病进行分子理解。
DOI：
10.1016/j.molmed.2006.07.003
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发表时间：
2006
影响因子：
13.6
通讯作者：
Alexander,Stephen
中科院分区：
文献类型：
--
作者：
Williams,RobinSB;Boeckeler,Katrina;Graf,Ralph;Muller-Taubenberger,Annette;Li,Zhiru;Isberg,RalphR;Wessels,Deborah;Soll,DavidR;Alexander,Hannah;Alexander,Stephen
社会变形虫Dictyosteelium discoideum越来越多地被用作一个简单的模型，调查的问题，是有关人类健康。本文重点介绍了最近几个基于网柄藻的生物医学研究实例，包括免疫细胞疾病和趋化性、中心体异常和无脑畸形、细菌细胞内发病机制以及神经保护和抗癌药物作用机制的分析。细胞，遗传和分子生物学技术的组合，可inDictyosteliumoften使这些问题的分析更适合在这个系统中比在哺乳动物细胞培养的研究。在这些领域利用网柄藻的发现推动了哺乳动物系统的研究，并将网柄藻作为人类疾病分析的有力模型。
The social amoebaDictyostelium discoideumis increasingly being used as a simple model for the investigation of problems that are relevant to human health. This article focuses on several recent examples ofDictyostelium-based biomedical research, including the analysis of immune-cell disease and chemotaxis, centrosomal abnormalities and lissencephaly, bacterial intracellular pathogenesis, and mechanisms of neuroprotective and anti-cancer drug action. The combination of cellular, genetic and molecular biology techniques that are available inDictyosteliumoften makes the analysis of these problems more amenable to study in this system than in mammalian cell culture. Findings that have been made in these areas usingDictyosteliumhave driven research in mammalian systems and have establishedDictyosteliumas a powerful model for human-disease analysis.