Predictors of changes in gait performance over four years in persons with late effects of polio
Predictors of changes in gait performance over four years in persons with late effects of polio
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DOI：
10.3233/nre-162057
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发表时间：
2017-01-01
影响因子：
2
通讯作者：
Brogardh, Christina
中科院分区：
文献类型：
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作者：
Flansbjer, Ulla-Britt;Lexell, Jan;Brogardh, Christina
背景：步态表现下降在脊髓灰质炎晚期效应患者中很常见。目的：确定脊髓灰质炎晚期效应患者四年内步态表现变化的预测因素。方法：对51名非卧床患者（平均年龄64岁，SD 6）进行了步态性能的评估，每年进行一次定时“起身和行走”（TUG），舒适和快速步态速度（CGS，FGS）和6分钟步行试验（6 MWT）。用Biodex测力计测量等速膝关节伸肌和屈肌肌力。使用混合线性模型分析步态表现的变化，并确定协变量性别、年龄、体重指数、出现新症状的时间、步态表现和膝关节肌肉力量的基线降低之间的任何变化预测因素。研究结果：三项步态性能测试随时间推移（每年减少）有显著的线性效应; CGS（0.8%; p < 0.05），FGS（1.7%; p < 0.001）和6 MWT（0.7%; p < 0.05），所有测试都有显著的随机效应。步态表现变化的最强预测因素是膝屈肌强度的个体差异（p < 0.001）。结论：小儿麻痹症晚期效应患者的步态表现随时间逐渐减少，主要取决于膝屈肌力量的个体差异。
BACKGROUND: Reduced gait performance is common in persons with late effects of polio. OBJECTIVE: To identify predictors of change in gait performance over four years in persons with late effects of polio. METHODS: Gait performance was assessed annually in 51 ambulatory persons (mean age 64 years, SD 6) by the Timed "Up & Go" (TUG), Comfortable and Fast Gait Speed (CGS, FGS), and 6-Minute Walk Test (6MWT). Isokinetic knee extensor and flexor muscle strength was measured with a Biodex dynamometer. Mixed Linear Models were used to analyze changes in gait performance and to identify any predictors of change among the covariates gender, age, body mass index, time with new symptoms, baseline reduction in gait performance and knee muscle strength. RESULTS: There were significant linear effects over time (reduction per year) for three gait performance tests; CGS (0.8%; p < 0.05), FGS (1.7%; p < 0.001), and 6MWT (0.7%; p < 0.05) with significant random effects for all tests. The strongest predictor of a change in gait performance was the individual variations in the knee flexor strength (p < 0.001). CONCLUSION: The small gradual reduction in gait performance over time in persons with late effects of polio is primarily determined by the individual variations in the knee flexor strength.