[Tailored therapy in treatment of Helicobacter pylori infectionbasedon clarithromycinsensitivity].
[Tailored therapy in treatment of Helicobacter pylori infectionbasedon clarithromycinsensitivity].
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DOI：
10.3760/cma.j.issn.0376-2491.2019.36.006
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发表时间：
2019-09-24
影响因子：
--
通讯作者：
Wang, J T
中科院分区：
文献类型：
--
作者：
Fan, X;Xue, Q;Wang, J T
目的：比较幽门螺杆菌（H. pylori）感染。方法：2015年7月至2018年1月，对H. pylori感染的患者随机分为克拉霉素四联疗法组和特制四联疗法组，进行为期14天的前瞻性研究。在定制治疗组中，根据克拉霉素敏感性调整药物。对照组给予质子泵抑制剂（PPI）、阿莫西林、克拉霉素和铋剂治疗。治疗4周后用尿素呼气试验评估根除情况。结果如下：在意向治疗分析和符合方案分析中，定制治疗组的H.pylori根除率[77.8%vs65.3%，P =0.001]均高于对照组[86.4%vs70.2%，P =0.001]。
Objective: To compare eradication rates and compliance of patients with Helicobacter pylori(H. pylori)infection based on clarithromycin sensitivity. Methods: From July 2015 to January 2018,patients with H. pylori infection in Peking university people's hospital were randomly assignedto a 14-day treatment with clarithromycin quadruple therapy versus tailored quadruple therapy for a prospective study. In the group of tailored therapy, medications were adjusted based on clarithromycin sensitivity. In the control group, all patients were given proton pump inhibitors (PPI), amoxicillin, clarithomycin and bismuth. Eradication status was assessed 4 weeks after treatment withurea breath test. Results: The H.pylori eradication rate were higher in the tailor therapy group than that in the control group in intention-to-treat[77.8% vs 65.3%,(P=0.001)] and per,protocol analyses [86.4% vs 70.2%,(P