Aptamer functionalized DNA hydrogels: Design, applications and kinetics
Aptamer functionalized DNA hydrogels: Design, applications and kinetics
复制标题
适体功能化 DNA 水凝胶：设计、应用和动力学
DOI：
10.1016/j.bios.2021.113597
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发表时间：
2021
影响因子：
12.6
通讯作者：
Feng Qu
中科院分区：
文献类型：
--
作者：
Liping Zhao;Linsen Li;Ge Yang;Bo Wei;Yao Ma;Feng Qu
DNA hydrogels have received considerable attention in various promising applications due to their excellent biocompatibility, controlled biodegradability, adjustable mechanical properties, stability against proteases, self-healing ability, and stimuli responsiveness. To obtain the specific molecular recognition capability, aptamers and many other functional motifs are utilized. Aptamers are short single-stranded DNA or RNA selected through SELEX to bind with specific target with high affinity and specificity. With advantages of broad range of targets, good stability, easy modification, and low cost, aptamer functionalized DNA hydrogels become popular in a wide range of promising applications. In this review, the recent progress on aptamer functionalized DNA hydrogels including general design principles, applications and kinetics has been summarized. Finally, the current challenges and prospects are discussed.
