C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes
C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes
复制标题
DOI：
10.1021/jacs.5b07677
复制
发表时间：
2015-09-30
影响因子：
15
通讯作者：
Chatani, Naoto
中科院分区：
文献类型：
--
作者：
Furukawa, Takayuki;Tobisu, Mamoru;Chatani, Naoto
尽管在芳烃的C-H键功能化方面取得了重大进展，但还没有关于均三甲苯等简单芳烃空间占据位置上的C-H键官能化的一般方法的报道。在此，我们报道了第一个用于芳烃和杂芳烃C-H硼化反应的铂基催化剂的开发。值得注意的是，这种方法对空间位阻表现出很高的耐受性，并提供了一系列2，6-二取代苯基硼酸酯的快速获取途径，这些都是进一步阐述的有价值的基础。
Despite significant progress in the area of C-H bond functionalization of arenes, no general method has been reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, we report the development of the first platinum-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to a series of 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.