Salmonella-induced enteritis: molecular pathogenesis and therapeutic implications
Salmonella-induced enteritis: molecular pathogenesis and therapeutic implications
复制标题
DOI：
10.1017/s1462399407000373
复制
发表时间：
2007-07-02
影响因子：
6.2
通讯作者：
Galyov, Edouard E.
中科院分区：
文献类型：
--
作者：
Layton, Abigail N.;Galyov, Edouard E.
沙门氏菌引起的肠炎是一种胃肠道疾病，在世界范围内造成重大的经济和福利问题。虽然感染通常是自限性的，但免疫功能低下的个体、年轻人和老年人等人群亚组容易发生更严重的全身感染。广泛的抗生素耐药性的出现和缺乏合适的疫苗对沙门氏菌引起的肠炎导致寻找替代的治疗策略。本文综述了沙门氏菌如何在分子水平上诱导肠炎的细菌因素，如III型分泌系统用于将细菌蛋白质的一个子集注射到宿主细胞，和宿主因素，如Toll样受体和细胞因子。III型分泌的细菌蛋白在宿主细胞中引起多种反应，导致肠炎。细胞因子形成宿主防御机制的一部分，但与细菌因素结合可导致沙门氏菌诱导的肠炎。我们还讨论了目前用于研究沙门氏菌引起的肠炎的动物和细胞培养模型，以及了解该疾病的机制如何影响沙门氏菌疗法的发展。
Salmonella-induced enteritis is a gastrointestinal disease that causes major economic and welfare problems throughout the world. Although the infection is generally self-limiting, subgroups of the population such as immunocompromised individuals, the young and the elderly are susceptible to developing more severe systemic infections. The emergence of widespread antibiotic resistance and the lack of a suitable vaccine against enteritis-causing Salmonella have led to a search for alternative therapeutic strategies. This review focuses on how Salmonella induces enteritis at the molecular level in terms of bacterial factors, such as the type III secretion systems used to inject a subset of bacterial proteins into host cells, and host factors, such as Toll-like receptors and cytokines. The type III secreted bacterial proteins elicit a variety of responses in host cells that contribute to enteritis. Cytokines form part of the host defence mechanism, but in combination with bacterial factors can contribute to Salmonella-induced enteritis. We also discuss animal and cell culture models currently used to study Salmonella-induced enteritis, and how understanding the mechanisms of the disease has impacted on the development of Salmonella therapeutics.