XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference
XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference
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DOI：
10.1063/1.5129406
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发表时间：
2020-05
期刊：
影响因子：
1.6
通讯作者：
Chi-Feng Huang;Wei-Hau Chang;Ting-Kuo Lee;Y. Joti;Y. Nishino;T. Kimura;A. Suzuki;Yoshitaka Bessho;Tsung-Tse Lee;Mei-Chun Chen;S. Yang;Y. Hwu;Shih-Hsin Huang;Po-Nan Li;Pei-Feng Chen;Yung-Chieh Tseng;Che Ma;T. Hsu;Chi-Huey Wong;K. Tono;T. Ishikawa;K. Liang
中科院分区：
文献类型：
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作者：
Chi-Feng Huang;Wei-Hau Chang;Ting-Kuo Lee;Y. Joti;Y. Nishino;T. Kimura;A. Suzuki;Yoshitaka Bessho;Tsung-Tse Lee;Mei-Chun Chen;S. Yang;Y. Hwu;Shih-Hsin Huang;Po-Nan Li;Pei-Feng Chen;Yung-Chieh Tseng;Che Ma;T. Hsu;Chi-Huey Wong;K. Tono;T. Ishikawa;K. Liang
目前，X射线自由电子激光（XFEL）相干衍射成像的空间分辨率受到XFEL注量的限制。在这里，我们澄清了这个问题，通过系统地研究与SPring-8埃紧凑型自由电子激光器XFEL上的金纳米粒子的大小从10 nm到80 nm的水溶液中的衍射。利用小角X射线散射方法沿着计算机模拟，定量分析了从单个XFEL脉冲获得的相干X射线衍射图样。结果表明，Au纳米粒子的可探测性可以用“主曲线”来描述，作为总电子密度、粒子尺寸和X射线能量密度的函数。然而，在目前的XFEL通量下检测小颗粒的困难，可以在很大程度上消除图像增强效应，通过附近的强散射纳米粒子的干扰。我们研究这种图像增强效果，通过定量分析从Au纳米粒子的两个粒子散射，并进一步，应用它来检测一个弱的生物对象的流感病毒的援助的Au纳米粒子。
The spatial resolution of x-ray free-electron laser (XFEL) coherent diffraction imaging is currently limited by the fluence of XFELs. Here, we clarify this issue by systematically studying the diffraction with a SPring-8 angstrom compact free electron laser XFEL on gold nanoparticles of size from 10 nm to 80 nm in water solution. The coherent x-ray diffraction patterns obtained from single XFEL pulses were quantitatively analyzed using a small-angle x-ray scattering scheme along with computer simulations. The results show that the detectability of Au nanoparticles can be described by a “master curve” as a function of total electron density, particle size, and x-ray fluence. The difficulty in detecting a small particle under the current XFEL fluence, however, could be largely eliminated by the image enhancement effect through interference from a strong scattering nanoparticle nearby. We investigate this image enhancement effect by quantitatively analyzing the two-particle scattering from Au nanoparticles, and further, applying it to detect a weak biological object of influenza virus with the aid of an Au nanoparticle.