Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice
Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice
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DOI：
10.1038/s41467-020-14363-4
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发表时间：
2020-01-28
影响因子：
16.6
通讯作者：
Hauser, Alan R.
中科院分区：
文献类型：
--
作者：
Bachta, Kelly E. R.;Allen, Jonathan P.;Hauser, Alan R.
与医疗保健相关的感染，如铜绿假单胞菌菌血症，对住院患者构成主要的临床风险。然而，这些全身性感染被认为是铜绿假单胞菌的“死胡同”，对传播没有任何影响。在这里，我们使用一个小鼠感染模型来表明铜绿假单胞菌可以从血液传播到胆囊，在那里它的复制数量非常高。然后，胆囊中的细菌可以在肠道和粪便中播种，导致传播给未受感染的笼子伴侣小鼠。我们的工作表明，在菌血症期间，胆囊对于铜绿假单胞菌从血液传播到粪便是至关重要的，在这个实验系统中，这一过程促进了传播。需要进一步的研究来测试这些发现在多大程度上与患者感染有关。
Health care-associated infections such as Pseudomonas aeruginosa bacteremia pose a major clinical risk for hospitalized patients. However, these systemic infections are presumed to be a "dead-end" for P. aeruginosa and to have no impact on transmission. Here, we use a mouse infection model to show that P. aeruginosa can spread from the bloodstream to the gall-bladder, where it replicates to extremely high numbers. Bacteria in the gallbladder can then seed the intestines and feces, leading to transmission to uninfected cage-mate mice. Our work shows that the gallbladder is crucial for spread of P. aeruginosa from the bloodstream to the feces during bacteremia, a process that promotes transmission in this experimental system. Further research is needed to test to what extent these findings are relevant to infections in patients.